{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:45:08Z","timestamp":1777434308845,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T00:00:00Z","timestamp":1096416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> of NAA, creatine and choline\u2010containing compounds were measured in posterior frontal white matter and occipital grey matter in 10 healthy human volunteers. Decay curves comprised signals from eight <jats:italic>TE<\/jats:italic> times ranging from 30 to 800\u2009ms with <jats:italic>TR<\/jats:italic> 2000\u2009ms acquired with a PRESS sequence on a 1.5\u2009T clinical scanner. Simulations were conducted to assess the precision of <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> estimates from decay curves comprising varying numbers and ranges of <jats:italic>TE<\/jats:italic> points. Mean and standard errors for <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>s of NAA, creatine and choline\u2010containing compounds were 300(8), 169(3) and 239(4) ms in posterior frontal white matter and 256(6), 159(8) and 249(8) ms in occipital grey matter. <jats:italic>In vivo<\/jats:italic> <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>s found for choline and NAA were shorter than the <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>s in the literature. The elevation of literature <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>s is accounted for by the simulation results, which demonstrated that there is a bias towards lengthened <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>s when <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> is measured with a maximum <jats:italic>TE<\/jats:italic> \u2248 <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>. Concentration estimates are at risk of being underestimated if previously reported <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> corrections are used. 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