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In order to identify putative MRI markers for de\u2010 and remyelination, we employed the cuprizone mouse model which leads to a selective and reversible demyelination of the corpus callosum with little or no axonal damage. Apart from histopathology, animals were studied with high\u2010resolution three\u2010dimensional MRI <jats:italic>in vivo<\/jats:italic> using multiple contrasts. While individual MRI findings significantly correlated with electron microscopy, the differentiation of regions with normal, demyelinated or remyelinated white matter by one contrast alone was less specific than by histology or electron microscopy. However, an accurate MRI prediction of the <jats:italic>in vivo<\/jats:italic> myelin status was achieved by a discriminant function analysis using a combination of <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>, <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> and magnetization transfer contrast. With a correct assignment of 95% of all animals examined, the procedure will allow for the survey of new therapeutic approaches aiming at improved remyelination. 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