{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:24:48Z","timestamp":1790367888533,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parenteral nutrition (PN) is frequently needed in neonatal intensive care. The use of standard PN has emerged as an easy\u2010to\u2010prescribe approach that allows one to have on\u2010site, ready\u2010to\u2010use PN. The aim of this study was to test the physicochemical stability and sterility of 2 specific PN solutions as well as simulate Y\u2010site compatibility with lipid injectable emulsions (ILE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study considered 2 standard ILE\u2013free PN solutions according to neonatal weight. These solutions were prepared in duplicate and stored at 4\u00b0C. The following physicochemical parameters were tested: visual alterations, turbidity, pH, osmolarity, and calcium concentration. Sterility was assessed by means of agar blood culture and glucose concentration determination. In addition, we assessed the stability of simulated Y\u2010site admixtures. For each standard ILE\u2010free PN solution, 2 3\u2010in\u20101 PN admixtures were designed, considering extreme values of fluid requirements (50 and 150 ml\/kg\/d) and a fat supply of 2 g\/kg\/24 h. The physicochemical parameters tested were phase separation and fat mean droplet size distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No alterations were detected by visual inspection. Calcium concentrations, turbidity, pH, and osmolarity values remained stable in all the determinations. All agar blood cultures were negative and glucose concentration was constant over time. Physical stability of simulated Y\u2010site admixtures was considered acceptable as mean droplet size distribution remained below 500 nm in all the emulsions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 2 tested standard ILE\u2010free PN solutions for neonates are physicochemically stable and sterile for 31 days under refrigeration (4\u00b0C). These solutions are also stable in case of Y\u2010site administration with ILE at the conditions tested.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10013","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T15:23:54Z","timestamp":1519226634000},"page":"694-700","source":"Crossref","is-referenced-by-count":15,"title":["Physicochemical Stability and Sterility of Standard Parenteral Nutrition Solutions and Simulated Y\u2010Site Admixtures for Neonates"],"prefix":"10.1002","volume":"33","author":[{"given":"Pau","family":"Riera","sequence":"first","affiliation":[{"name":"Pharmacy Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Faculty of Pharmacy and Food Sciences Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Garrido\u2010Alejos","sequence":"additional","affiliation":[{"name":"Pharmacy Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Cardenete","sequence":"additional","affiliation":[{"name":"Pharmacy Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisenda","family":"Moliner","sequence":"additional","affiliation":[{"name":"Neonatal Unit Department of Paediatrics Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Zapico\u2010Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cardona","sequence":"additional","affiliation":[{"name":"Pharmacy Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-9453","authenticated-orcid":false,"given":"Noe","family":"Garin","sequence":"additional","affiliation":[{"name":"Pharmacy Department Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Instituto de Salud Carlos III Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426506021004374"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615580596"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1695-4033(02)77889-2"},{"issue":"9","key":"e_1_2_6_5_1","first-page":"641","article-title":"Parenteral nutrition in neonatology\u2014to standardize or individualize?","volume":"8","author":"Riskin A","year":"2006","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.3.892"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/62.11.1177"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-10-47"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710402800285"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(96)00394-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114521833"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.7.101"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.7.43"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2010.04.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108314768"},{"key":"e_1_2_6_16_1","volume-title":"The European Society for Clinical Nutrition and Metabolism (ESPEN) book\u2014Basics in Clinical Nutrition","author":"Sobotka L","year":"2011"},{"key":"e_1_2_6_17_1","unstructured":"The American Society for Parenteral and Enteral Nutrition.The A.S.P.E.N. 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