{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:42:09Z","timestamp":1766047329597,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to determine serum thiamin concentrations in critically ill medical patients who required chronic diuretic drug treatment before admission to a medical intensive care unit (ICU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study was performed in a medical ICU. Subjects who received diuretic drug therapy for at least 6\u00a0months prior to ICU admission constituted the diuretic group. The control group was clinically matched adults admitted to the same ICU but without a history of diuretic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 50 subjects were included (25 subjects in each of the diuretic and control groups). In the diuretic group, daily dose of furosemide prior to admission was 40\u00a0mg\/d (range of\u00a020\u2013160\u00a0mg\/d). In all subjects, the ICU admission baseline blood thiamin concentrations were 31.2\u00a0\u00b1\u00a027.1\u00a0ng\/mL. In the diuretic group, the baseline whole blood thiamin level was significantly lower compared with levels in the control group (15.5\u00a0\u00b1\u00a010.7 vs 46.8\u00a0\u00b1\u00a029.5\u00a0ng\/mL; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). On day 2 after entry, thiamin levels remained low (23.2\u00a0\u00b1\u00a015.4\u00a0ng\/mL in the diuretic group vs 49\u00a0\u00b1\u00a038\u00a0ng\/mL in the control group; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Low thiamin levels were found in 96% of patients at baseline and in 72% of patients on the second day in the diuretic group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adults receiving chronic diuretic therapy and then requiring medical ICU care commonly exhibit thiamin depletion on admission to the ICU and during the initial days of ICU care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10241","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T08:47:37Z","timestamp":1547542057000},"page":"565-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Thiamin Status in Adults Receiving Chronic Diuretic Therapy Prior to Admission to a Medical Intensive Care Unit: A Pilot Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Kursat","family":"Gundogan","sequence":"first","affiliation":[{"name":"Division of Medical Intensive Care Department of Medicine Enteral and Parenteral Nutrition Unit Erciyes University School of Medicine  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail Hakki","family":"Akbudak","sequence":"additional","affiliation":[{"name":"Division of Medical Intensive Care Department of Medicine Enteral and Parenteral Nutrition Unit Erciyes University School of Medicine  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadir","family":"Bulut","sequence":"additional","affiliation":[{"name":"Division of Medical Intensive Care Department of Medicine Enteral and Parenteral Nutrition Unit Erciyes University School of Medicine  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahin","family":"Temel","sequence":"additional","affiliation":[{"name":"Division of Medical Intensive Care Department of Medicine Enteral and Parenteral Nutrition Unit Erciyes University School of Medicine  Kayseri 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University Hospital  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Support Service Emory University Hospital  Atlanta Georgia USA"},{"name":"Division of Endocrinology Metabolism and Lipids Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200409000-00010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515000203"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.2.410"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00262893"},{"issue":"12","key":"e_1_2_7_6_1","first-page":"1362","article-title":"Wernicke\u2010Korsakoff syndrome not related to alcohol use: a 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