{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:23:30Z","timestamp":1792293810785,"version":"4.4.0"},"reference-count":116,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The metabolism of the essential trace element copper remains incompletely understood and, until recently, nearly ignored in acute medicine. Menkes disease was for long the only known copper deficiency condition, but several case reports and investigations conducted over the last 2 decades have shown that deficiency is more frequent than previously suspected, with devastating individual consequences and potential public health consequences. The copper needs in healthy individuals are 0.9\u00a0mg\/d, which translates to 0.3\u00a0mg\/d intravenously in parenteral nutrition; the present review aims at gathering actual knowledge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and results<\/jats:title>\n                    <jats:p>A review of literature was conducted in PubMed and Cochrane systematic reviews to identify the most recent information about copper deficiency and generate a narrative review. Copper deficiency has hereditary and acquired origins, the latter being the most frequent. Clinical manifestations are nonspecific but affect all organs and systems, particularly the hematologic (anemia) and the neurologic (myeloneuropathy) systems. Deficiency also affects the cardiovascular, cutaneous, and immune systems. Severe copper deficiency due to reduced absorption after bariatric bypass surgery has become frequent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Deficiency is more frequent than previously recognized, probably because of changing nutrition patterns but also because of some treatments that have become very common such as bypass bariatric surgery and, in acute medicine, prolonged continuous renal replacement therapy. The patients may present with severe hematologic and neurologic complications that go untreated because copper deficiency was not considered in the differential diagnosis: These complications often need active intravenous repletion with doses 4\u20138 times the usual nutrition recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.10328","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T22:54:07Z","timestamp":1560812047000},"page":"504-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":171,"title":["Copper Deficiency: Causes, Manifestations, and Treatment"],"prefix":"10.1002","volume":"34","author":[{"given":"Marco","family":"Altarelli","sequence":"first","affiliation":[{"name":"Adult Intensive Care and Burn Unit Centre Hospitalier Universitaire Vaudois (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-5223","authenticated-orcid":false,"given":"Nawfel","family":"Ben\u2010Hamouda","sequence":"additional","affiliation":[{"name":"Adult Intensive Care and Burn Unit Centre Hospitalier Universitaire Vaudois (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Schneider","sequence":"additional","affiliation":[{"name":"Adult Intensive Care and Burn Unit Centre Hospitalier Universitaire Vaudois (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-1648","authenticated-orcid":false,"given":"Mette M.","family":"Berger","sequence":"additional","affiliation":[{"name":"Adult Intensive Care and Burn Unit Centre Hospitalier Universitaire Vaudois (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.489S"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.960S"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-014-9736-5"},{"key":"e_1_2_9_5_1","first-page":"224","volume-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc","author":"Institute of Medicine Panel of Micronutrients, Board Food and Nutrition","year":"2001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.952S"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(01)00078-5"},{"key":"e_1_2_9_8_1","first-page":"27","article-title":"Copper","volume":"7","author":"Aubert H","year":"2014","journal-title":"Dev Soil Sci"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70190-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/42.4.681"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000784"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2016.02.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.64.1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.1054S"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/109.11.1979"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-100102421"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1613"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-010-0006-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/b800799c"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2015.4253"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.4.736"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.07.041"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.1017S"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2016.09.012"},{"issue":"3","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1542\/peds.34.3.324","article-title":"Copper deficiency in infancy","volume":"34","author":"Cordano A","year":"1964","journal-title":"Pediatrics"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.017"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.1054S"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.1012S"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.11.2464"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.6.803"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.01.021"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-5-199409010-00021"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616673190"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.04.008"},{"key":"e_1_2_9_35_1","unstructured":"Survey British Artificial Nutrition. BANS Report 2016: Artificial Nutrition Support in the UK 2005\u20132015. Adult Home Parenteral Nutrition & Home Intravenous Fluids.https:\/\/www.bapen.org.uk\/images\/pdfs\/reports\/bans-report-2016.pdf"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1525"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/49.3.573"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80449-9"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607183007006563"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426504019003305"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607100024006361"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614538457"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.04.024"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533612446706"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114549255"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112463942"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104988"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032015000200004"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3407-5"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2017.1351289"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)61177-4"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01050.x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2666-x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200604000-00009"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-010-0316-7"},{"key":"e_1_2_9_56_1","unstructured":"Society British Obesity and Metabolic Surgery.BOMSS Guidelines on peri\u2010operative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery. Published2014."},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-016-2162-8"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290200044019"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202837"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90445-3"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199103000-00015"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.001222"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00081-7"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(92)90035-S"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.03.028"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/44.6.899"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2005.04.026"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199601000-00019"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.2.410"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199901000-00057"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617716618"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000181468"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/47.5.896"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014342"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.02.008"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02083017"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.5.757"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3773-6"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8120826"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250123"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2012.03.008"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3407-5"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517001349"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.3.855S"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394390-3.00006-9"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617713955"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1322583"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2010.02.002"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000092"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.70"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002558"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.1064S"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.2.365"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12392"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(97)00004-1"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(85)90180-7"},{"issue":"8","key":"e_1_2_9_97_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/jn\/123.8.1343","article-title":"Copper deficiency increases the susceptibility of lipoproteins and tissues to peroxidation in rats","volume":"123","author":"Rayssiguier Y","year":"1993","journal-title":"J Nutr"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.02.007"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216648805"},{"key":"e_1_2_9_100_1","unstructured":"World Health Organization.Trace elements in human nutrition and health.1996. ISBN 92 4 156173 4 (NLM Classification: QU 130).http:\/\/www.who.int\/iris\/handle\/10665\/37931"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.023812"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507798951"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.2005.B1045"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.03.024"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.614"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480120078302"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.08.037"},{"issue":"4","key":"e_1_2_9_108_1","first-page":"545","article-title":"Australasian Society for Parenteral and Enteral Nutrition guidelines for supplementation of trace elements during parenteral nutrition","volume":"23","author":"Osland EJ","year":"2014","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.07.009"},{"key":"e_1_2_9_110_1","first-page":"151","article-title":"Zinc\u2010 and copper\u2010replacement therapy\u2014a must in burns and scalds in children?","volume":"14","author":"Pochon P","year":"1981","journal-title":"Prog Ped Surg"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.02.012"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.01.025"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117721908"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20461"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12020"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020633"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.07.010"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fncp.10328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:03:25Z","timestamp":1760951005000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.10328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":116,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/ncp.10328"],"URL":"https:\/\/doi.org\/10.1002\/ncp.10328","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2019-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}