{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:38:27Z","timestamp":1761007107589,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D deficiency during critical illness has been associated with worsened outcomes. Because most critically ill patients with severe traumatic injuries are vitamin D deficient, we investigated the efficacy and safety of cholecalciferol therapy for these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three patients (&gt;17\u00a0years of age) admitted to the trauma intensive care unit who had a serum 25\u2010hydroxy vitamin D (25\u2010OH vit D) concentration &lt;20\u00a0ng\/mL were given 10,000\u00a0IU of cholecalciferol daily. Efficacy was defined as achievement of a 25\u2010OH vit D of 30\u201379.9\u00a0ng\/mL. Safety was evaluated by the presence of hypercalcemia (serum ionized calcium [iCa] &gt;1.32\u00a0mmol\/L) or hypervitaminosis D (25\u2010OH vit D &gt;79.9 nmol\/L). Patients were monitored for 2\u00a0weeks during cholecalciferol therapy. <jats:italic>Results<\/jats:italic>: Twenty\u2010four patients (45%) achieved target 25\u2010OH vit D. No patients experienced hypervitaminosis D. Hypercalcemia occurred in 40% (n = 21) of patients; 2 patients experienced an iCa &gt;1.49 nmol\/L. 25\u2010OH vit D was significantly greater for those who developed hypercalcemia (37.2 + 11.2 vs 28.4 + 5.6\u00a0ng\/mL, respectively, <jats:italic>P<\/jats:italic> &lt; 0.001) by the second week of cholecalciferol. Of 24 patients who achieved target 25\u2010OH vit D, 14 (58%) experienced hypercalcemia in contrast to 24% of patients (7 out of 29) who did not achieve target 25\u2010OH vit D (<jats:italic>P<\/jats:italic> = 0.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cholecalciferol normalized serum 25\u2010OH vit D concentrations in less than half of patients yet was associated with a substantial proportion of patients with hypercalcemia without hypervitaminosis D.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10407","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T00:33:31Z","timestamp":1570840411000},"page":"933-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients"],"prefix":"10.1002","volume":"35","author":[{"given":"Whitney L.","family":"Holmes","sequence":"first","affiliation":[{"name":"Department of Pharmacy Regional One Health  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"George O.","family":"Maish","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayle","family":"Minard","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Croce","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-6317","authenticated-orcid":false,"given":"Roland N.","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13790"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206ccdf"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31822d74f3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112444449"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31829eb7af"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000210"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10585"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-016-0054-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.10.029"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.05.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.13204"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2472-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4846-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318256de1b"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607109335307"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.01.018"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9341"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.07.021"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00793-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113499374"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197403000-00001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199610000-00011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.6000\/1927-5951.2017.07.03.6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.02.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112458526"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.172155"},{"key":"e_1_2_7_29_1","unstructured":"25\u2010OH vitamin D ARCHITECT package insert. 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