{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:39:44Z","timestamp":1790375984244,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aggressive nutrition may benefit early growth; nevertheless, effects on neurodevelopmental outcomes are unclear. We planned a descriptive analytical study to compare survival without neurodevelopment disability (NDD) at 1 year in 2 groups during 2 time epochs\u2014before and after implementation of early optimal nutrition strategies. NDD was defined as any one of the following: mental and\/or motor development quotient &lt; 85 at 12 months of age, corrected for prematurity; Denver Developmental Screening Test abnormal\/suspect in even 1 domain out of the 4 domains; seizures; requirement of hearing aid; or blindness in 1 or both eyes. We also compared mortality, survival without bronchopulmonary dysplasia, necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), intraventricular hemorrhage, periventricular leukomalacia, sepsis, metabolic bone disease (MBD), and extrauterine growth restriction (EUGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preterm neonates born between 27 and 32 weeks\u2019 gestation were included. The prospective study group (AO) was recruited after implementation of early optimal nutrition policy. The comparative retrospective cohort (BO) received nutrition based on clinicians\u2019 decisions. Both groups were followed up using a structured plan till 1 year corrected age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>137 neonates were enrolled in AO and 151 in the BO cohort. There was no statistically significant difference in survival without NDD at 1 year\u201475.5% in AO vs 72.1% in BO, odds ratio 0.84 (95% CI 0.5\u20131.6). Babies who received early optimal nutrition had less NEC, EUGR, and ROP requiring laser therapy but more MBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no difference in survival without NDD in early optimal nutrition cohort compared to the cohort before implementation of the nutrition strategy. Short\u2010term benefits themselves may justify the need for early optimal nutrition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10422","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T14:11:05Z","timestamp":1571839865000},"page":"708-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcome of Very Preterm Infants With Early Optimal Nutrition Strategy: A Comparative Cohort Study"],"prefix":"10.1002","volume":"35","author":[{"given":"Swati","family":"Upadhyay","sequence":"first","affiliation":[{"name":"Department of Neonatology Kerala Institute of Medical Sciences  Trivandrum Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-6003","authenticated-orcid":false,"given":"Femitha","family":"Pournami","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kerala Institute of Medical Sciences  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