{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:20:37Z","timestamp":1787163637672,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Since the introduction of percutaneous endoscopic gastrostomy in the 1980s, the prevalence of home enteral nutrition (HEN) support has increased significantly. Despite these increases, many patients are unable to tolerate standard polymeric formulas (SPFs), resulting in significant healthcare resource utilization. Peptide\u2010based diets (PBDs) have emerged as a viable option in SPF\u2010intolerant patients; however, data in the HEN population are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of our prospectively maintained HEN database was conducted to assess tolerance, efficacy, and impact on healthcare utilization in patients on PBDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From January 1, 2016, to May 1, 2018, 95 patients were placed on PBDs, with 53 patients being started directly and 42 patients being transitioned from SPFs. In patients transitioned to PBDs, symptoms of nausea and vomiting, diarrhea, abdominal pain, and distention improved significantly. Healthcare utilization also declined significantly, including mean number of phone calls (1.8 \u00b1 1.6 to 1.1 \u00b1 0.9,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006), mean number of emergency room visits (0.3 \u00b1 0.6 to 0.09 \u00b1 0.3,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.015), and mean number of provider visits (1.3 \u00b1 1.3 to 0.3 \u00b1 0.5,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, PBDs were well tolerated and resulted in significant improvements in symptoms of gastrointestinal distress and healthcare utilization in patients intolerant to SPFs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.10477","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T06:25:36Z","timestamp":1583735136000},"page":"487-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Reduction in Healthcare Utilization With Transition to Peptide\u2010Based Diets in Intolerant Home Enteral Nutrition Patients"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-3544","authenticated-orcid":false,"given":"Manpreet S.","family":"Mundi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-5586","authenticated-orcid":false,"given":"Saketh","family":"Velapati","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind R.","family":"Kuchkuntla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Hurt","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533610368702"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.04.022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617718472"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"1","article-title":"Enteral nutrition at home and in nursing homes: an 11\u2010year (2002\u20102012) epidemiological analysis","volume":"62","author":"Paccagnella A","year":"2016","journal-title":"Minerva Gastroenterol Dietol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.01.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.01.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21044"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrt144"},{"issue":"5","key":"e_1_2_7_10_1","article-title":"Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances","author":"Gomes CAR","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115621863"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114526450"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115627142"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12302"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90645-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v6.i2.22"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.5.922"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24845"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i2.306"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616663635"},{"issue":"4","key":"e_1_2_7_21_1","first-page":"226","article-title":"Medium chain triglycerides (MCT) formulas in paediatric and allergological practice","volume":"11","author":"\u0141o\u015b\u2010Rycharska E","year":"2016","journal-title":"Prz Gastroenterol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(99)00106-4"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117742595"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(99)80016-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069144"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.64"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.06.085"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607190014005501"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719702100114"},{"issue":"6","key":"e_1_2_7_30_1","first-page":"507","article-title":"Long\u2010term effects of early nutritional support with new enterotropic peptide\u2010based formula vs. standard enteral formula in HIV\u2010infected patients: randomized prospective trial","volume":"9","author":"Chlebowski R","year":"1993","journal-title":"Nutrition"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710603000101"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v8.i10.700"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615591602"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1510"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616662992"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/JXX.0000000000000009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616661011"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2018.0227"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110377797"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.14740\/gr1192"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fncp.10477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ncp.10477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:48:59Z","timestamp":1760971739000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.10477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,9]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/ncp.10477"],"URL":"https:\/\/doi.org\/10.1002\/ncp.10477","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,9]]},"assertion":[{"value":"2020-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}