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Parenteral nutrition was administered from day +2 following ASCR, as she was unable to tolerate nasogastric feeds because of grade IV mucositis and vomiting. On day +12, she developed worsening metabolic acidosis with above reportable levels of lactic acid. Given the patient's well clinical appearance and paucity of evidence of end\u2010organ dysfunction on physical examination and on laboratory studies, there was high suspicion that the patient's lactic acidosis did not result from tissue hypoxia and was, in fact, a type B lactic acidosis. Thiamin was empirically administered, with rapid improvement in lactic acidosis. Thiamin deficiency was later confirmed by laboratory studies drawn prior to thiamin administration.<\/jats:p>","DOI":"10.1002\/ncp.10560","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T04:26:29Z","timestamp":1595478389000},"page":"414-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lactic Acidosis Secondary to Thiamin Deficiency Following Autologous Stem Cell Transplantation"],"prefix":"10.1002","volume":"36","author":[{"given":"Kim R","family":"Derespina","sequence":"first","affiliation":[{"name":"Children's Hospital at Montefiore  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-5322","authenticated-orcid":false,"given":"Shubhi","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Children's Hospital at Montefiore  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"Mahadeo","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"McCabe","sequence":"additional","affiliation":[{"name":"Children's Hospital at Montefiore  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/80.4.484"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066605278644"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1309483"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2289"},{"issue":"6","key":"e_1_2_5_6_1","first-page":"579","article-title":"Severe lactic acidosis due to thiamine deficiency after bone marrow transplantation in a child with acute monocytic leukemia","volume":"75","author":"Rovelli A","year":"1990","journal-title":"Haematologica"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704893"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2012.53.5.1049"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073814560628"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114545128"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614561790"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.02.021"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1984.tb08626.x"},{"key":"e_1_2_5_14_1","article-title":"Nutritional risk factors predict severe acute graft\u2010versus\u2010host disease and early mortality in pediatric allogeneic hematopoietic stem cell transplantation","author":"Kerby EH","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701502"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2016.00016"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113511992"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fncp.10560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ncp.10560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:50:27Z","timestamp":1760968227000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.10560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/ncp.10560"],"URL":"https:\/\/doi.org\/10.1002\/ncp.10560","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,23]]},"assertion":[{"value":"2020-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}