{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:08:34Z","timestamp":1787987314531,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lingual linear lesions (LLLs) are the oral linear lesions located on the dorsum, lateral borders, and\/or ventral surface of tongue. It has been suggested that LLLs might be an early clinical sign of vitamin B<jats:sub>12<\/jats:sub> deficiency. Here, a retrospective study was conducted to further investigate and validate the association between LLL and vitamin B<jats:sub>12<\/jats:sub> deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the clinical examination, patients with LLLs were enrolled and analyzed retrospectively. Data regarding clinical and laboratory features were obtained. Follow\u2010up was done at least 6 months following appropriate supplementation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 57 patients, consisting of 20 males and 37 females with a mean age of 59.12 years (range, 18\u201380), were enrolled in this study. The hematological examination revealed that 56 (98.25%) of the 57 patients had severe serum vitamin B<jats:sub>12<\/jats:sub> deficiency, and the other 1 patient had a borderline low level of vitamin B<jats:sub>12<\/jats:sub>. All the enrolled patients responded well to cobalamin replacement therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LLLs might be a clinical sign strongly suggestive of severe vitamin B<jats:sub>12<\/jats:sub> deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10596","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T14:56:45Z","timestamp":1604069805000},"page":"1041-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lingual Linear Lesions: A Clinical Sign Strongly Suggestive of Severe Vitamin B<sub>12<\/sub> Deficiency"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4412-7498","authenticated-orcid":false,"given":"Zhe\u2010Xuan","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Shanxi Provincial People's Hospital  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hospital Infection Control Shanxi Provincial People's Hospital  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Dong","family":"Fang","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Faculty of Medicine and Dentistry University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.06.009"},{"issue":"11","key":"e_1_2_8_3_1","first-page":"1381","article-title":"Oral manifestations of systemic disease","volume":"82","author":"Chi AC","year":"2010","journal-title":"Am Fam 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