{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:10:22Z","timestamp":1791828622793,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with cystic fibrosis (CF) are at risk of altered body composition (BC). Newborn screening (NBS) may lead to improved BC outcomes. We investigated BC and its relationship with lung function in prepubertal children diagnosed with CF by NBS. Secondary aims explored predictors of fat\u2010free mass (FFM) and lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven screened (non\u2010meconium ileus) children with CF (20 boys) born 2007\u20132012 had a dual\u2010energy x\u2010ray absorptiometry scan at 5\u20138 years to determine whole\u2010body (WB) and appendicular BC. Anthropometry was performed and routine spirometry recorded. Results were converted to <jats:italic>z<\/jats:italic>\u2010scores, height\u2010adjusted (fat mass index [FMI] and FFM index [FFMI]) and compared with population mean values. Predictors of forced expiratory volume in 1 second (FEV<jats:sub>1<\/jats:sub>) were assessed using linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Height, body mass index (BMI), and FEV<jats:sub>1<\/jats:sub> were within normal limits, however, weight and BC were significantly low compared with reference data (weight, <jats:italic>P =<\/jats:italic> .03; WB FMI, <jats:italic>P =<\/jats:italic> .001; WB FFMI, <jats:italic>P =<\/jats:italic> .009). Gender differences were detected, with lower appendicular BC in boys and lower weight, BMI, and BC in girls. The association between FEV<jats:sub>1<\/jats:sub> and WB FFMI (<jats:italic>r<\/jats:italic> = 0.38; <jats:italic>P =<\/jats:italic> .02) was stronger than with BMI (<jats:italic>r<\/jats:italic> = 0.29; <jats:italic>P =<\/jats:italic> .08). WB FFMI was the only significant predictor of FEV<jats:sub>1<\/jats:sub> in a multivariable model (95% CI, 0.11\u20130.99; <jats:italic>P =<\/jats:italic> .016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this NBS CF population, gender differences in growth and BC were apparent despite preserved lung function. These results support BC assessment in prepubertal children, particularly girls, with an opportunity to direct interventions to optimize FFM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10604","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T20:47:49Z","timestamp":1607633269000},"page":"1240-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Growth, Body Composition, and Lung Function in Prepubertal Children with Cystic Fibrosis Diagnosed by Newborn Screening"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-4153","authenticated-orcid":false,"given":"Elizabeth","family":"Owen","sequence":"first","affiliation":[{"name":"Dietetics Department Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Population, Policy and Practice University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7937-2728","authenticated-orcid":false,"given":"Gwyneth","family":"Davies","sequence":"additional","affiliation":[{"name":"Infection, Immunity and Inflammation Research and Teaching Department University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Wallis","sequence":"additional","affiliation":[{"name":"Respiratory Unit Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L","family":"Grant","sequence":"additional","affiliation":[{"name":"St George's University of London  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-3444","authenticated-orcid":false,"given":"Mary S","family":"Fewtrell","sequence":"additional","affiliation":[{"name":"Department of Population, Policy and Practice University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"issue":"7","key":"e_1_2_7_2_1","first-page":"1","article-title":"Measuring body composition","volume":"91","author":"Wells JC","year":"2006","journal-title":"Arch Dis 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