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Most patients experience peripheral, gravity\u2010dependent edema; however, serious cases exhibit anasarca and ascites. Many long\u2010term complications of the disease exist due to the underlying pathology and the therapies used for treatment, including metabolic bone disease, micronutrient deficiencies, and hyperlipidemia. Pharmacologic and nutrition interventions are key to appropriate management. Fluid and sodium restriction in combination with corticosteroids, albumin, and diuretics are used to manage edema. Steroid\u2010sparing therapies like alkylating agents and calcineurin inhibitors and dietary modification to eliminate dairy and gluten may be warranted in patients with frequent relapses or steroid\u2010refractory disease. Nutrition clinicians should familiarize themselves with the nuances of treating this disease to optimize care for children with nephrotic syndrome.<\/jats:p>","DOI":"10.1002\/ncp.10622","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T23:25:45Z","timestamp":1611098745000},"page":"331-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pediatric Nephrotic Syndrome: Pharmacologic and Nutrition Management"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-3764","authenticated-orcid":false,"given":"Kyle J.","family":"Hampson","sequence":"first","affiliation":[{"name":"Division of Pharmacy Practice, Arnold and Marie Schwartz College of Pharmacy and Health Sciences Long Island University  Brooklyn New York USA"},{"name":"Division of Pharmacotherapy Services The Brooklyn Hospital Center  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan L.","family":"Gay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Connecticut Children's  Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly E.","family":"Band","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-04883-5.50018-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14184-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2012.04.323"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2017.1374003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05000516"},{"key":"e_1_2_8_7_1","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group.KDIGO clinical practice guideline for glomerulonephritis.2012;2(2):139\u2010274."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2018.08.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.36-3-117"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.2.179"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-43596-0_24"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01453686"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00205"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.006940"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3716-2"},{"issue":"4","key":"e_1_2_8_16_1","first-page":"818","article-title":"Magnesium in pediatric nephrotic syndrome","volume":"120","author":"Teslariu O","year":"2016","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"e_1_2_8_17_1","volume-title":"Dietary Reference Intakes for Sodium and Potassium","author":"Oria M","year":"2019"},{"key":"e_1_2_8_18_1","unstructured":"Prednisone.In: Specific Lexicomp Online Database [database on the Internet]. 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