{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:09:19Z","timestamp":1787072959614,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cannabinoids have been used medicinally for thousands of years. Clinical trials support their use for treatment of chemotherapy\u2010induced nausea and vomiting and HIV\u2010 and AIDS\u2010related anorexia. Cancer anorexia cachexia syndrome (CACS) is a common debilitating condition and is associated with poor prognosis. The 2016 European Society for Parenteral and Enteral Nutrition clinical guidelines on nutrition in cancer patients concluded that \u201cthere are insufficient consistent clinical data to recommend cannabinoids to improve taste disorders or anorexia in cancer patients.\u201d The increased attention that cannabinoids have received in recent years warrants an updated evaluation of the literature on this topic, as practitioners are likely to encounter cancer patients interested in cannabinoid use. A systematic literature search was performed to assess the current body of evidence concerning cannabinoid use for the stimulation of appetite and oral intake by cancer patients. Over the past 20 years, 6 randomized controlled trials have evaluated the impact of cannabinoids on appetite\u2010related outcomes in oncology patients in comparison with a control group or placebo. Based on this literature, cannabinoids do not appear to improve appetite, oral intake, weight, chemosensory function, or appetite\u2010related quality of life. Limitations of the literature include small sample sizes, lack of adjustment for confounding variables, and difficulties conducting true placebo\u2010controlled trials with a drug that may result in psychoactive side effects. Further exploration of the impact of cannabinoid use on CACS by using large, well\u2010designed clinical trials is needed.<\/jats:p>","DOI":"10.1002\/ncp.10639","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T09:22:32Z","timestamp":1614936152000},"page":"793-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cannabinoid use for appetite stimulation and weight gain in cancer care: Does recent evidence support an update of the European Society for Clinical Nutrition and Metabolism clinical guidelines?"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1713-8607","authenticated-orcid":false,"given":"Stephani","family":"Johnson","sequence":"first","affiliation":[{"name":"School of Health Professions Rutgers University  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-7546","authenticated-orcid":false,"given":"Jane","family":"Ziegler","sequence":"additional","affiliation":[{"name":"School of Health Professions Rutgers University  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-6748","authenticated-orcid":false,"given":"David A.","family":"August","sequence":"additional","affiliation":[{"name":"School of Health Professions Rutgers University  Newark New Jersey USA"},{"name":"Division of Surgical Oncology Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA"},{"name":"Department of Surgery Rutgers\u2010Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"issue":"2","key":"e_1_2_4_2_1","first-page":"85","article-title":"Cannabis use in palliative oncology: a review of the evidence for popular indications","volume":"19","author":"Turgeman I","year":"2017","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.5912\/jcb709"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.108"},{"issue":"1","key":"e_1_2_4_5_1","first-page":"1","article-title":"ESPEN guidelines on nutrition in cancer patients","volume":"36","author":"Arends J","year":"2016","journal-title":"Clin Nutr"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.06.008"},{"issue":"1","key":"e_1_2_4_7_1","first-page":"117","article-title":"Cannabis for the management of cancer symptoms: THC version 2.0? 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