{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:20Z","timestamp":1761007580574,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is a rare, inherited, multisystemic autosomal recessive disorder caused by mutations in the nuclear <jats:italic>TYMP<\/jats:italic> gene. This syndrome is characterized by ptosis, external ophthalmoplegia, gastrointestinal dysmotility, cachexia, peripheral neuropathy, and leukoencephalopathy. Our case illustrates a patient diagnosed with MNGIE and cachexia who has benefited from the initiation and maintenance of parenteral nutrition.\u00a0We highlight the benefits of receiving long\u2010term supplementary home parenteral nutrition under close monitoring for patients with this neurogastrointestinal disease in order to gain weight and maintain good health.<\/jats:p>","DOI":"10.1002\/ncp.10726","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T07:03:48Z","timestamp":1624604628000},"page":"361-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intensive nutrition support may benefit patients with a rare mitochondrial disorder"],"prefix":"10.1002","volume":"37","author":[{"given":"Arezina","family":"Kasti","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics Attikon University General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-722X","authenticated-orcid":false,"given":"Maroulla","family":"Nikolaki","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Attikon University General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Pyrousis","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Attikon University General Hospital  Athens Greece"},{"name":"Faculty of Medicine, University of Patras  Patra Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalliopi","family":"Synodinou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Attikon University General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Oikonomopoulos","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens Attikon University General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Triantafyllou","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit, 2nd Department of Internal Medicine\u2014Propaedeutic, Medical School National and Kapodistrian University of Athens, Attikon University General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1002\/ana.410280308"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1002\/jimd.12300"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.7762\/cnr.2015.4.2.132"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1186\/s13023-019-1016-6"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1002\/jpen.1455"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1016\/j.clnu.2020.03.005"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1002\/jpen.1421"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_1","DOI":"10.1159\/000346260"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.15403\/jgld.2014.1121.273.kuc"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.1093\/brain\/awv226"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.1016\/j.hemonc.2014.12.001"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.1007\/s00415-012-6572-9"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1007\/s00415-012-6500-z"},{"unstructured":"Mitochondrial neurogastrointestinal encephalomyopathy. 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