{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:51:25Z","timestamp":1788565885409,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric patients undergoing intestinal rehabilitation (IR) using parenteral nutrition (PN) are at higher risk for intestinal failure\u2013associated liver disease (IFALD). Nutrition support, growth, and liver enzymes must be closely monitored while incorporating hepatoprotective lipid injectable emulsions for optimal patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Describe trends of liver profile and nutrition outcomes for pediatric patients undergoing IR using SMOFlipid[SO,MCT,OO,FO\u2010ILE]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After IRB approval, patients undergoing IR using SO,MCT,OO,FO\u2010ILE were observed prospectively from January 1, 2017, through December 1, 2019. The following values were documented monthly: aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TB), triene\/tetraene ratio (TTR), micronutrient and trace element levels, <jats:italic>z<\/jats:italic>\u2010scores for growth, and nutrition support regimen. Values were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The group involved 16 pediatric patients for an average of 16.4 months on SO,MCT,OO,FO\u2010ILE. By the end of the study, mean PN hours per day decreased by 34.7%, <jats:italic>P<\/jats:italic> &lt; 0.0001. Mean PN calories per kilogram decreased from 60.4 to 48.3, <jats:italic>P<\/jats:italic> = 0.004. SO,MCT,OO,FO\u2010ILE calories met the recommended dietary intake goal of 30% at the average 1.6 g\/kg. Growth <jats:italic>z<\/jats:italic>\u2010scores increased in those &lt;2 YOA , although the body mass index decreased in our &gt;2 YOA cohort. Total nutrition received from PN decreased to 62%: a 32% change, <jats:italic>P<\/jats:italic> = 0.001. There were no statistically significant changes in AST or ALT. TB decreased by 67.08%, <jats:italic>P<\/jats:italic> &lt;0.05. No essential fatty acid deficiency was reported (TTR &lt; 0.02). There were no changes in micronutrient and trace element deficiencies. There was zero new incidences of IFALD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SO,MCT,OO,FO\u2010ILE may be used long term in pediatric patients while promoting growth and development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10782","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T19:42:45Z","timestamp":1633722165000},"page":"1180-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Trends in liver profile and nutrition outcomes in children undergoing intestinal rehabilitation using a mixed lipid injectable emulsion"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-6918","authenticated-orcid":false,"given":"Jessica","family":"Wassef","sequence":"first","affiliation":[{"name":"Salah Foundation Children's Hospital at Broward Health Medical Center  Fort Lauderdale Florida USA"},{"name":"Hackensack Meridian Health at Palisades Medical Center  North Bergen New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lipkin","sequence":"additional","affiliation":[{"name":"Salah Foundation Children's Hospital at Broward Health Medical Center  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hardigan","sequence":"additional","affiliation":[{"name":"Kiran C. Patel College of Allopathic Medicine at Nova Southeastern University  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6239-4007","authenticated-orcid":false,"given":"Debora","family":"Duro","sequence":"additional","affiliation":[{"name":"Salah Foundation Children's Hospital at Broward Health Medical Center  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb12159.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.066"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181373b91"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.12.049"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70021-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607105029003186"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.03.036"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000189360.84169.da"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-018-4422-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115626921"},{"key":"e_1_2_10_12_1","unstructured":"Food and Drug Administration.Full Prescribing Information. 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