{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:14:42Z","timestamp":1785554082921,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070579"],"award-info":[{"award-number":["82070579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In patients suffering from small\u2010intestinal enteroatmospheric fistula who are receiving enteral nutrition (EN), although the function of the small intestine is sufficient, without chyme reinfusion (CR), disuse of the distal intestine of enteroatmospheric fistula may occur. However, CR reverses such pathological changes and have an influence on improving outcomes following definitive surgery (DS) for small\u2010intestinal enteroatmospheric fistula. This study attempted to investigate the effect of preoperative CR in patients with EN on the outcomes after DS for small\u2010intestinal enteroatmospheric fistula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>According to whether CR was performed between January 2012 and December 2019, patients receiving DS for small intestinal enteroatmospheric fistula were divided into the CR group and non\u2010CR group. The effect of preoperative CR was then investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 159 patients were finally enrolled, of which 72 patients were in the CR group and 87 patients were in the non\u2010CR group. A total of 47 (29.56%) patients were found to have recurrent fistula after DS, the recurrent fistula rate in the CR group (multivariate odds ratio = 0.557; 95% CI, 0.351\u20130.842; <jats:italic>P<\/jats:italic> = 0.019) was lower. CR was also shown to promote postoperative recovery of bowel function (hazard ratio [HR] = 1.982; 95% CI, 1.199\u20133.275; <jats:italic>P<\/jats:italic> = 0.008), and shorten postoperative length of stay (LOS) (HR = 1.739; 95% CI, 1.233\u20132.453; <jats:italic>P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative CR may reduce the incidence of recurrent fistula, time to return of bowel function and postoperative LOS following DS for small\u2010intestinal enteroatmospheric fistula.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10823","type":"journal-article","created":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T12:33:40Z","timestamp":1643546020000},"page":"634-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Chyme reinfusion improved outcomes after definitive surgery for small\u2010intestinal enteroatmospheric fistula in patients with enteral nutrition"],"prefix":"10.1002","volume":"37","author":[{"given":"Yannian","family":"Liao","sequence":"first","affiliation":[{"name":"Medical College of Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of General Surgery  Nanjing 83 Hospital Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-4041","authenticated-orcid":false,"given":"Zheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Enterocutaneous Fistula Surgery Jiangning Hospital  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of General Surgery Jinling Hospital  Nanjing Jiangsu 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