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An overview of acid\u2010base physiology, the different acid\u2010base disorders encountered in practice, a stepwise approach to evaluate arterial blood gases, and other key diagnostic tools helpful in formulating a safe and effective medical and nutrition plan are covered in this acid\u2010base primer. Case scenarios are also provided for the application of principles and the development of clinical skills.<\/jats:p>","DOI":"10.1002\/ncp.10881","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T01:18:45Z","timestamp":1656206325000},"page":"980-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acid\u2010base disorders: A primer for clinicians"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3431-0106","authenticated-orcid":false,"given":"Anne M.","family":"Tucker","sequence":"first","affiliation":[{"name":"Division of Pharmacy, Clinical Pharmacy Specialist\u2014Critical Care\/Nutrition Support University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-1315","authenticated-orcid":false,"given":"Tami N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Pharmacy, Clinical Pharmacy Specialist\u2014Emergency Medicine University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07400715"},{"key":"e_1_2_10_3_1","volume-title":"Pharmacotherapy: A Pathophysiologic Approach. 11th ed","author":"Devlin JW","year":"2020"},{"key":"e_1_2_10_4_1","volume-title":"Brenner & Rector's The Kidney","author":"Yu ASL","year":"2019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111429794"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1003327"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"KimY MassieL MurataGH TzamaloukasAH.Discrepancy between measured serum total carbon dioxide content and bicarbonate concentration calculated from arterial blood gases.Cureus.2015;7(12):e398.","DOI":"10.7759\/cureus.398"},{"key":"e_1_2_10_8_1","first-page":"113","volume-title":"The ASPEN Adult Nutrition Support Core Curriculum","author":"Canada TW","year":"2017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04040413"},{"key":"e_1_2_10_10_1","volume-title":"ASPEN fluids, electrolytes, and acid\u2010base disorders handbook","author":"Bruno J","year":"2020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0685-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu289"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","unstructured":"MehtaAN EmmettJB EmmettM.GOLD MARK: an anion gap mnemonic for the 21st century.Lancet.2008;372(9642):892.","DOI":"10.1016\/S0140-6736(08)61398-7"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ncp.10881","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:21:17Z","timestamp":1760952077000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.10881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,25]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/ncp.10881"],"URL":"https:\/\/doi.org\/10.1002\/ncp.10881","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,25]]},"assertion":[{"value":"2022-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}