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Fluid administration is a common treatment for hypotension and shock in early sepsis. Fluid therapy can also cause edema and organ dysfunction. Research on the best treatment strategies for sepsis has provided insights on the optimal timing, dose, and type of fluid to treat patients with sepsis. Initial research on early goal\u2010directed therapy for sepsis included an initial bolus of 30\u2009ml\/kg of fluid, but more recent research has supported use of smaller volumes. After initial fluid resuscitation, minimizing additional fluid administration may be beneficial, but no single measure has been established as the best method to guide ongoing fluid management in sepsis. Dynamic measures of \u201cfluid responsiveness\u201d can predict which patients will experience an increase in cardiac output from a fluid bolus. Use of such a measure in clinical care remains limited by applicability to patient populations and uncertainty regarding the effect on clinical outcomes. Recent research informs the effect of fluid composition on outcomes for patients with sepsis. Current data support the use of balanced crystalloids, rather than saline, and the use of crystalloids, rather than semisynthetic colloids. The role for albumin administration in sepsis remains uncertain. Future research should focus on determining the optimal volume of fluid during sepsis resuscitation, the effectiveness of measures of \u201cfluid responsiveness\u201d in improving outcomes, the optimal composition of crystalloid solutions, the role of albumin, and the effects of \u201cderesuscitation\u201d after septic shock.<\/jats:p>","DOI":"10.1002\/ncp.10892","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T07:57:57Z","timestamp":1657267077000},"page":"990-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Intravenous fluid therapy in sepsis"],"prefix":"10.1002","volume":"37","author":[{"given":"Kevin P.","family":"Seitz","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward 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