{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:14:32Z","timestamp":1767136472375,"version":"build-2238731810"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastrointestinal and sensory manifestations (GSMs) of coronavirus disease 2019 (COVID\u201019) may affect food intake, resulting in malnutrition and poor outcomes. We characterized the impact of GSMs and oral nutrition supplementation on energy\u2010protein intake (EPI) and hospital discharge in adult patients with COVID\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients from two hospitals were enrolled (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009357). We recorded the presence and type of GSM at admission, estimated energy requirements (EER) and the EPI based on regular food intake (plate diagram sheets) during hospital stays. Patients not achieving 60% of their EER from food over 2 consecutive days received oral nutrition supplementation (ONS) with a high\u2010energy\u2010protein oral drink.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most patients (63.6%) presented with GSMs at admission. Anorexia was the most common manifestation (44%). Patients with anorexia or more than one GSMs were more likely to not achieve 60% EER on the first day of follow\u2010up and to require the ONS intervention (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.050). Prevalence of at least one GSM was higher in patients who did not achieve hospital discharge than in patients who achieved it (74.2% vs 54.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.038). The patients requiring ONS (26.9%) demonstrated good adherence to the intervention (79.3%), achieved their EER during 95.7% of the supplementation time, and presented with hospital discharge rates similar to patients not requiring ONS (92.2% vs 91.9%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20091.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GSM were prevalent in COVID\u201019 and it impaired EER attendance and patient recovery. ONS was well\u2010tolerated, aided EER attendance, and potentially facilitated hospital discharge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.10906","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T08:12:10Z","timestamp":1662624730000},"page":"1152-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal and sensory manifestations, nutrition management, and energy\u2010protein intake in hospitalized patients with COVID\u201019"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-3995","authenticated-orcid":false,"given":"Raquel Susana","family":"Torrinhas","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Laboratory of Nutrition and Surgery Metabolic of the Digestive Tract (LIM 35), School of Medicine (FMUSP) University of S\u00e3o Paulo S\u00e3o Paulo 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Nutrition Hospital de Caridade S\u00e3o Vicente de Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds Nunes","family":"Freire","sequence":"additional","affiliation":[{"name":"Division of Nutrition Hospital de Caridade S\u00e3o Vicente de Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marli Alves Ramelho","family":"da Silva","sequence":"additional","affiliation":[{"name":"Division of Nutrition Hospital de Caridade S\u00e3o Vicente de Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Ruotolo","sequence":"additional","affiliation":[{"name":"Nutrition Therapy Service Sociedade Beneficente de Senhoras Hospital S\u00edrio\u2010Liban\u00eas de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Hummel","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Nutrition Therapy Service Sociedade Beneficente de Senhoras Hospital S\u00edrio\u2010Liban\u00eas de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janayna Nayara","family":"Buzato","sequence":"additional","affiliation":[{"name":"Nutrition Therapy Service Sociedade Beneficente de Senhoras Hospital S\u00edrio\u2010Liban\u00eas de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique Oliveira","family":"e Silva","sequence":"additional","affiliation":[{"name":"Nutrition Therapy Service Sociedade Beneficente de Senhoras Hospital S\u00edrio\u2010Liban\u00eas de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Laboratory of Nutrition and Surgery Metabolic of the 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