{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:22:57Z","timestamp":1791894177498,"version":"4.3.4"},"reference-count":100,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic injury results in drastic changes to a patient's normal physiology. The hormonal stress response, as well as some treatment strategies, lead to significant disruptions in electrolyte homeostasis that are important for clinicians to understand. In addition, advances in fluid resuscitation and modern transfusion practices have led to their own unique set of consequences, which we are just beginning to appreciate. Special attention is placed on rhabdomyolysis, as this distinct entity represents an extreme example of injury induced electrolyte derangements. This review describes the physiologic response to trauma and highlights some of the important electrolyte abnormalities that can be encountered while caring for the injured patient.<\/jats:p>","DOI":"10.1002\/ncp.10908","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T05:53:50Z","timestamp":1661752430000},"page":"1004-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Trauma\u2010related electrolyte disturbances: From resuscitation to rhabdomyolysis"],"prefix":"10.1002","volume":"37","author":[{"given":"Kyla A.","family":"Fredrickson","sequence":"first","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-2152","authenticated-orcid":false,"given":"Thomas W.","family":"Carver","sequence":"additional","affiliation":[{"name":"Department of Trauma and Acute Care Surgery Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.1.109"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199310000-00008"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.20.4.306"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718000400209"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072053"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-012-0284-5"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(71)90293-5"},{"key":"e_1_2_14_9_1","first-page":"1215","article-title":"Aggressive early crystalloid resuscitation adversely affects outcomes in adult blunt trauma patients: an analysis of the Glue Grant database","volume":"74","author":"Kasotakis G","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0252"},{"key":"e_1_2_14_11_1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1213\/ANE.0000000000005431","article-title":"Association between ionized calcium concentrations during hemostatic transfusion and calcium treatment with mortality in major trauma","volume":"132","author":"Chanthima P","year":"2021","journal-title":"Anesth Analg"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318230089e"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.s3-4.1.16"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1261819"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000200"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2014.06.013"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480294"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14050460"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-01118-8"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32834458af"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000108885.37811.CA"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.09.013"},{"key":"e_1_2_14_23_1","doi-asserted-by":"crossref","unstructured":"Bhasin\u2010ChhabraB VeitlaV WeinbergS KoratalaA.Demystifying hyponatremia: A clinical guide to evaluation and management.Nutr Clin Pract.2022:1\u201010.doi:10.1002\/ncp.10907","DOI":"10.1002\/ncp.10907"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2021.05.005"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11937"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318265f576"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000135"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1692-0"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9052"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-016-0311-7"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000152535.97968.4E"},{"key":"e_1_2_14_32_1","first-page":"1045","article-title":"A physicochemical approach to acid\u2010base balance in critically ill trauma patients minimizes errors and reduces inappropriate plasma volume expansion","volume":"66","author":"Kaplan LJ","year":"2009","journal-title":"J Trauma"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32833c0957"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620978735"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1751143718786113"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-00928-0"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2658-4"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318295feba"},{"key":"e_1_2_14_39_1","first-page":"S17","article-title":"PlasmaLyte","volume":"70","author":"Rizoli S","year":"2011","journal-title":"J Trauma"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-19-24"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200208000-00002"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199401000-00010"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000245029.47106.db"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198607000-00018"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03070906"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.05.009"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.10.002"},{"key":"e_1_2_14_48_1","first-page":"S86","article-title":"Hyperkalemia after packed red blood cell transfusion in trauma patients","volume":"64","author":"Aboudara MC","year":"2008","journal-title":"J Trauma"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkt042"},{"key":"e_1_2_14_50_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1051\/ject\/201244060","article-title":"Modification of sodium, glucose, potassium, and osmolarity in packed red blood cells and fresh frozen plasma using a desktop hemoconcentrator setup","volume":"44","author":"Striker CW","year":"2012","journal-title":"J Extra Corpor Technol"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.12.065"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000239516.49799.63"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2004.07.016"},{"key":"e_1_2_14_54_1","first-page":"391","article-title":"Admission ionized calcium levels predict the need for multiple transfusions: a prospective study of 591 critically ill trauma patients","volume":"70","author":"Magnotti LJ","year":"2011","journal-title":"J Trauma"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12272"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607104028003133"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002312"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000171840.01892.36"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003027"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.12.036"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2017-206717"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002570"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607107031003228"},{"key":"e_1_2_14_64_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/hdi.12010","article-title":"Phosphorus, phosphorous, and phosphate","volume":"17","author":"Iheagwara OS","year":"2013","journal-title":"Hemodial Int"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10011"},{"key":"e_1_2_14_66_1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/0884533616662988","article-title":"Hypophosphatemia in enterally fed patients in the surgical intensive care unit","volume":"32","author":"Fuentes E","year":"2016","journal-title":"Nutr Clin Pract"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200006000-00057"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003271"},{"key":"e_1_2_14_69_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190978","article-title":"Hyperphosphatemia is associated with high mortality in severe burns","volume":"13","author":"Kuo G","year":"2018","journal-title":"PLoS One"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607187011004364"},{"key":"e_1_2_14_71_1","first-page":"205","article-title":"Phosphate disorders and the clinical management of hypophosphatemia and hyperphosphatemia","volume":"67","author":"Garc\u00eda Mart\u00edn A","year":"2020","journal-title":"Endocrinol Diabetes Nutr (Engl Ed)"},{"key":"e_1_2_14_72_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/cc2978","article-title":"Bench\u2010to\u2010bedside review: rhabdomyolysis\u2014an overview for clinicians","volume":"9","author":"Huerta\u2010Alardin AL","year":"2005","journal-title":"Crit Care"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480407001013"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40719-016-0038-y"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000933"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1314-5"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2016"},{"key":"e_1_2_14_78_1","doi-asserted-by":"crossref","DOI":"10.1136\/tsaco-2021-000836","article-title":"Rhabdomyolysis: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document","volume":"7","author":"Kodadek L","year":"2022","journal-title":"Trauma Surg Acute Care Open"},{"key":"e_1_2_14_79_1","first-page":"1","article-title":"Rhabdomyolysis: advances in diagnosis and treatment","volume":"14","author":"Parekh R","year":"2012","journal-title":"Emerg Med Pract"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.09.020"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24606"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-015-1204-1"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-021-00924-3"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12815"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(98)00089-1"},{"key":"e_1_2_14_86_1","unstructured":"BurgessS.Rhabdomyolysis: an evidence\u2010based approach.J Intensive Care Soc.2021:1\u20105."},{"key":"e_1_2_14_87_1","article-title":"Role of bicarbonates and mannitol in rhabdomyolysis: a comprehensive review","volume":"12","author":"Somagutta MR","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.08.050"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801327"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2006.043265"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP59326"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.151"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(97)70011-8"},{"key":"e_1_2_14_94_1","article-title":"Comparison of IV insulin dosing strategies for hyperkalemia in the emergency department","volume":"2","author":"Moussavi K","year":"2020","journal-title":"Crit Care Explor"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-0645-1"},{"issue":"6","key":"e_1_2_14_96_1","article-title":"Continuous renal replacement therapy (CRRT) for rhabdomyolysis","volume":"15","author":"Zeng X","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2007.06.037"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340100878"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(89)90328-2"},{"key":"e_1_2_14_100_1","first-page":"164","article-title":"Heterotopic ossification and rhabdomyolysis","volume":"33","author":"Bethoux F","year":"1995","journal-title":"Paraplegia"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.891046"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ncp.10908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:21:48Z","timestamp":1760952108000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.10908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":100,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/ncp.10908"],"URL":"https:\/\/doi.org\/10.1002\/ncp.10908","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"assertion":[{"value":"2022-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}