{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:49:31Z","timestamp":1783010971915,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic analgesic use is described in home parenteral nutrition (HPN)\u2013dependent patients, but there are limited data on factors associated with opioid use for noncancerous pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients attending a national UK intestinal failure reference center were divided in two groups according to strong opioid (SO) usage; risk factors for SO usage were analyzed using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 168 HPN\u2010dependent patients were included. During the study period, 73 patients (43.5%) had documented SO usage (SO group), whereas the remainder did not (No\u2010SO group). The prevalence of Crohn's disease among the No\u2010SO group was twofold higher than among the SO group (43.2% vs 24.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.013), whereas those with surgical complications were twice as prevalent among the SO group (19.2% vs 8.4%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.04). The rate of working\u2010age unemployment was significantly higher in the SO group (90.6%) than the No\u2010SO group (55.6%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Multivariate regression showed unemployment as an independent risk factor for SO usage (OR, 6.005; 95% CI, 1.435\u201325.134), whereas Crohn's disease (OR, 0.284; 95% CI, 0.09\u20130.898) and &lt;4 intravenous support (IVS) nights per week (OR, 0.113; 95% CI, 0.012\u20131.009) were protective factors. The life\u2010long incidence of catheter\u2010related bloodstream infection (CRBSI) was comparable between groups (34.2% SO vs 27.4% No\u2010SO; <jats:italic>P<\/jats:italic>\u2009=\u20090.336).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SO use is frequent among HPN\u2010dependent patients and associated with high rates of unemployment and \u22654 IVS nights per week, but not with increased rate of CRBSI. The reduced usage among patients with Crohn's disease warrants further evaluation but might be due to the chronicity as compared with other IF etiologies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10916","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T02:10:09Z","timestamp":1664763009000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors associated with strong opioid use for noncancer pain in patients with chronic intestinal failure"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5022-4318","authenticated-orcid":false,"given":"Liat","family":"Deutsch","sequence":"first","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust  Salford UK"},{"name":"Department of Gastroenterology and Liver Diseases, Tel\u2010Aviv Sourasky Medical Centre, affiliated to Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-2729","authenticated-orcid":false,"given":"Anabelle","family":"Cloutier","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust  Salford UK"},{"name":"CHU de Qu\u00e9bec Universit\u00e9 Laval  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Leahy","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust  Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Teubner","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust  Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Abraham","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust  Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Taylor","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust  Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Paine","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Salford Royal NHS Foundation Trust  Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lal","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust  Salford UK"},{"name":"Academic Health Sciences Centre University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1516204"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001384"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1464"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4792"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00161-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2559"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051528"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1614972"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.02.432"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.105784"},{"issue":"43","key":"e_1_2_7_13_1","first-page":"1487","article-title":"Vital signs: overdoses of prescription opioid pain relievers\u2014United States, 1999\u20132008","volume":"60","author":"Centers for Disease Control and Prevention (CDC).","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_14_1","unstructured":"Centers for Disease Control and Prevention NCfIPaC. 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