{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:07:40Z","timestamp":1784736460712,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to define the existing barriers for early enteral nutrition (EEN) in critically ill children and to analyze the differences in nutrient supply, complications, and outcomes between EEN and late EN (LEN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a secondary analysis of a multicenter observational, prospective study including critically ill children receiving EN. Variables analyzed included demographic and anthropometric features, caloric and nutrient supply, outcomes, and complications according to the EN onset. Patients were classified into two groups according to the start of EN: 24\u2010EEN vs EN started after 24\u2009h (24\u2010LEN) and 48\u2010EEN vs EN started after 48\u2009h (48\u2010LEN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010eight children were enrolled; 22.1% received 24\u2010EEN, and 67.6% received 48\u2010EEN. EN was most frequently delayed in patients older than 12 months, in patients with cardiac disease, and in those requiring mechanical ventilation (MV). Children in the 24\u2010EEN group had shorter duration of MV compared with those in the 24\u2010LEN group (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). The 48\u2010EEN group received a higher caloric intake (<jats:italic>P<\/jats:italic>\u2009=\u20090.04), reached the caloric target earlier (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and had lower incidence of constipation (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) than the 48\u2010LEN group. There was a positive correlation between the time required to reach the maximum caloric intake and the length of pediatric intensive care stay (<jats:italic>r<\/jats:italic>\u2009=\u20090.46; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EEN may improve nutrient delivery, reduce time on MV, and prevent constipation in critically ill children. No relevant differences between 24\u2010EEN and 48\u2010EEN were found. Cardiac disease, MV, and age older than 12 months were risk factors associated with LEN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.10922","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T07:11:40Z","timestamp":1666336300000},"page":"442-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Early vs late enteral nutrition in pediatric intensive care unit: Barriers, benefits, and complications"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-2528","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Solana","sequence":"first","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n University Hospital Madrid Spain"},{"name":"Research Network on Maternal and Child Health and Development (RedSAMID) Madrid Spain"},{"name":"Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Manrique","sequence":"additional","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n University Hospital Madrid Spain"},{"name":"Research Network on Maternal and Child Health and Development (RedSAMID) Madrid Spain"},{"name":"Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Slocker","sequence":"additional","affiliation":[{"name":"Research Network on Maternal and Child Health and Development (RedSAMID) Madrid Spain"},{"name":"Cl\u00ednico Universitario de la Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyes","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"H. Central Universitario de Asturias Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Gil","sequence":"additional","affiliation":[{"name":"H. Regional Universitario de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Yun","sequence":"additional","affiliation":[{"name":"H. Regional Universitario de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Redondo","sequence":"additional","affiliation":[{"name":"H. Universitario de Cruces Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Balaguer","sequence":"additional","affiliation":[{"name":"H. Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"H. Nuestra Se\u00f1ora de la Candelaria Santa Cruz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aranzazu","family":"Gonz\u00e1lez\u2010Posada","sequence":"additional","affiliation":[{"name":"H. Universitario Doce de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Go\u00f1i","sequence":"additional","affiliation":[{"name":"Complejo hospitalario de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Mar\u00eda","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"H. Virgen de la Salud Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Santiago","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Ciudad de Ja\u00e9n Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"H. Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mi\u00f1ambres","sequence":"additional","affiliation":[{"name":"H. Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"L\u00f3pez\u2010Herce","sequence":"additional","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n University Hospital Madrid Spain"},{"name":"Research Network on Maternal and Child Health and Development (RedSAMID) Madrid Spain"},{"name":"Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"},{"name":"Maternal and Child Public Health Department, School of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117711387"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05922-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31822d71a6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533609335176"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.01.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001525"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.110993"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2000.tb02699.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710102500281"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(03)00033-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200112000-00005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200104000-00004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(02)00200-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.12.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002382"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000527"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002602"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001321"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512003042"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508159049"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.01.046"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002135"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.06.046"},{"issue":"7","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.14423\/SMJ.0000000000000314","article-title":"When should a patient with a nonvariceal upper gastrointestinal bleed be fed?","volume":"108","author":"Rassameehiran S","year":"2015","journal-title":"South Med J"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112436978"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A083"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ncp.10922","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.10922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:58:36Z","timestamp":1760950716000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.10922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/ncp.10922"],"URL":"https:\/\/doi.org\/10.1002\/ncp.10922","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"assertion":[{"value":"2022-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}