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The loss of mucosal absorptive area after extensive intestinal resection is accompanied by an accelerated transit and hypersecretion. Changes in physiology and clinical outcomes differ between patients with SBS with or without the distal ileum and\/or colon\u2010in\u2010continuity. This narrative review summarizes the treatments used in SBS, with a focus on novel approaches with intestinotrophic agents. During the early postoperative years, spontaneous adaptation occurs and can be induced or accelerated with conventional therapies, which include dietary and fluid modifications and antidiarrheal and antisecretory drugs. Based on the proadaptive role of enterohormones (eg, glucagon\u2010like peptide [GLP]\u20102), analogues have been developed to allow enhanced or hyperadaptation after a period of stabilization. Teduglutide is the first GLP\u20102 analogue developed and commercialized with proadaptive effects resulting in reduced parenteral support needs; however, the potential for weaning of parenteral support is variable. Whether early treatment with enterohormones or accelerated hyperadaptation would further improve absorption and outcomes remains to be shown. Longer\u2010acting GLP\u20102 analogues are currently being investigated. Encouraging reports with GLP\u20101 agonists require confirmation in randomized trials, and dual GLP\u20101 and GLP\u20102 analogues have yet to be clinically investigated. Future studies will prove whether the timing and\/or combinations of different enterohormones will be able to break the ceiling of intestinal rehabilitation in SBS.<\/jats:p>","DOI":"10.1002\/ncp.10974","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T09:55:51Z","timestamp":1682675751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of short bowel syndrome: Breaking the therapeutic ceiling?"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-4996","authenticated-orcid":false,"given":"Lucas","family":"Wauters","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Gastroenterology and Nutrition Support, Assistance Publique des Hopitaux de Paris University of Paris Clichy 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