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Various etiologies result in SBS\u2010IF, with three primary anatomical subtypes occurring following intestinal resection. Depending on the extent and segment(s) of the intestine resected, malabsorption can be nutrient specific or sweeping; however, such issues and the associated prognosis for the patient can be predicted with analysis of the residual intestine, along with baseline nutrient and fluid deficits and extent of malabsorption. The provision of parenteral nutrition\/intravenous (PN\u2010IV) fluids and antisymptomatic agents is fundamental; however, optimal management should focus on intestinal rehabilitation, wherein intestinal adaptation is prioritized and PN\u2010IV fluids are weaned over time. Key strategies to maximize intestinal adaptation include hyperphagic consumption of an individualized SBS diet and the appropriate use of trophic agents, such as a glucagon\u2010like peptide 2 analog.<\/jats:p>","DOI":"10.1002\/ncp.10991","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T09:55:51Z","timestamp":1682675751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Anatomical and physiological considerations in short bowel syndrome: Emphasis on intestinal adaptation and the role of enterohormones"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-6476","authenticated-orcid":false,"given":"Kelly A.","family":"Tappenden","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Nutrition, College of Applied Health Sciences University of Illinois at Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10964"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2426"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114525210"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113520005"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.07.002"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.07.004"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10951"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00218.2007"},{"key":"e_1_2_14_10_1","first-page":"127","article-title":"The effect of extensive resections of the small intestine","volume":"23","author":"Flint JM","year":"1912","journal-title":"Bull Johns Hopkins Hosp"},{"issue":"3","key":"e_1_2_14_11_1","first-page":"233","article-title":"Resection of the small intestine in rats. 3. 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