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Patients with SBS\u2010IF are unable to absorb sufficient nutrients or fluids to maintain significantly metabolic homeostasis via oral or enteral intake alone and require long\u2010term intravenous supplementation (IVS), consisting of partial or total parenteral nutrition, fluids, electrolytes, or a combination of these. The goal of medical and surgical treatment for patients with SBS\u2010IF is to maximize intestinal remnant absorptive capacity so that the need for IVS support may eventually be reduced or eliminated. Daily subcutaneous administration of the glucagon\u2010like peptide 2 analog, teduglutide, has been shown to be clinically effective in reducing IVS dependence and potentially improving the health\u2010related quality of life of patients with SBS\u2010IF. The management of patients with SBS\u2010IF is complex and requires close monitoring. This narrative review discusses the use of teduglutide for patients with SBS\u2010IF in clinical practice. The screening of patient eligibility for teduglutide treatment, initiation, monitoring of efficacy and safety of treatment, adapting or weaning off IVS, and the healthcare setting needed for SBS\u2010IF management are described, taking into consideration data from clinical trials, observational studies, and clinical experience.<\/jats:p>","DOI":"10.1002\/ncp.11015","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T11:27:29Z","timestamp":1686310049000},"page":"141-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Use of teduglutide in adults with short bowel syndrome\u2013associated intestinal failure"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-8330","authenticated-orcid":false,"given":"Loris","family":"Pironi","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"},{"name":"Centre for Chronic Intestinal Failure\u2014Clinical Nutrition and Metabolism Unit, IRCCS AOUBO Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8956-7059","authenticated-orcid":false,"given":"Johane P.","family":"Allard","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Toronto General Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Joly","sequence":"additional","affiliation":[{"name":"Service de Gastro\u2010ent\u00e9rologie, MICI et Assistance Nutritive Universit\u00e9 de Paris, H\u00f4pital Beaujon, Centre de R\u00e9f\u00e9rence des Maladies Digestives Rares, Assistance Publique\u2010H\u00f4pitaux de Paris Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parnia","family":"Geransar","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International AG Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Genestin","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International AG Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich\u2010Frank","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology Asklepios Klinik St. Georg Hamburg Germany"},{"name":"Department of Hepatology and Gastroenterology Campus Virchow Klinikum and Charit\u00e9 Mitte Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Gattex(teduglutide). 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