{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:50:38Z","timestamp":1767898238010,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypovitaminosis C is prevalent in critically ill patients. Continuous renal replacement therapy (CRRT) clears vitamin C, increasing the risk for vitamin C deficiency. However, recommendations for vitamin C supplementation in critically ill patients receiving CRRT vary widely, from 250\u2009mg\/day to 12\u2009g\/day. This case report describes a patient who developed a severe vitamin C deficiency after prolonged CRRT despite receiving ascorbic acid (450\u2009mg\/day) supplementation in her parenteral nutrition. This report summarizes recent research investigating vitamin C status in critically ill patients receiving CRRT, discusses the patient case, and provides recommendations for clinical practice. In critically ill patients receiving CRRT, the authors of this manuscript suggest providing at least 1000\u2009mg\/day of ascorbic acid to prevent vitamin C deficiency. Baseline vitamin C levels should be checked in patients who are malnourished and\/or have other risk factors for vitamin C deficiency, and vitamin C levels should be monitored thereafter every 1\u20132 weeks.<\/jats:p>","DOI":"10.1002\/ncp.11022","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T10:58:51Z","timestamp":1686308331000},"page":"235-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe vitamin C deficiency associated with continuous renal replacement therapy: A case report"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-8275","authenticated-orcid":false,"given":"Ryan","family":"Burslem","sequence":"first","affiliation":[{"name":"Department of Clinical and Preventive Nutrition Sciences Rutgers University Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Clinical and Preventive Nutrition Sciences Rutgers University Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kapil","family":"Rajwani","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Weill Cornell Medical College New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Clinical and Preventive Nutrition Sciences Rutgers University Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020615"},{"key":"e_1_2_8_3_1","unstructured":"National Institutes of Health.Vitamin C: fact sheet for health professionals. Accessed November 16 2022.https:\/\/ods.od.nih.gov\/factsheets\/VitaminC-HealthProfessional\/#h7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2022.05.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10914"},{"key":"e_1_2_8_6_1","unstructured":"Ascorbic acid. Lexi\u2010Drugs. Lexicomp;2022. Accessed November 20 2022.http:\/\/online.lexi.com\/"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70244-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1891-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.02.025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110377205"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000220"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.08.037"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199901000-00057"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.09.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.422"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03347-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2200-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2115-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.01.028"},{"key":"e_1_2_8_20_1","unstructured":"Centers for Disease Control and Prevention.Trace elements: selenium. Accessed April 2 2023.https:\/\/www.cdc.gov\/nutritionreport\/pdf\/nr_ch4b.pdf"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2378"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0912"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb29302.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.07.004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000323"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617716618"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58115-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2021.100813"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2967-z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665118002501"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000146012.44570.20"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000142"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3704"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.11022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:35:52Z","timestamp":1760952952000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.11022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/ncp.11022"],"URL":"https:\/\/doi.org\/10.1002\/ncp.11022","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,9]]},"assertion":[{"value":"2023-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}