{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:03Z","timestamp":1761007563741,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>What kind of feeding should be provided during therapeutic hypothermia (TH) in patients with large hemispheric infarction (LHI) is not clear. Therefore, we conducted a retrospective observational study to determine whether providing early postpyloric feeding (PPF) (&lt;24\u2009h after admission) is beneficial or harmful for patients with this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively screened 78 patients with LHI who were treated with TH from one neurological intensive care unit (ICU). The patients were receiving either early PPF (<jats:italic>n<\/jats:italic>\u2009=\u200952) or early parenteral nutrition (PN) (<jats:italic>n<\/jats:italic>\u2009=\u200926). Data regarding 30\u2010day mortality, neurological outcome, nutrition\u2010related laboratory indicators, ICU hospitalization time, mechanical ventilation (MV) duration, and complications were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A greater number of patients who received early PPF had favorable neurologic outcome than those who received early PN (57.7% vs 30.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.025). The early PPF group had a lower severity of pulmonary infection than the early PN group, as measured by the Clinical Pulmonary Infection Score (7.33\u2009\u00b1\u20090.96 vs 9.42\u2009\u00b1\u20092.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). The total protein and hemoglobin levels in the early PPF group were higher than those in the early PN group (59.56\u2009\u00b1\u20095.09 vs 56.52\u2009\u00b1\u20097.94\u2009g\/L, <jats:italic>P<\/jats:italic>\u2009=\u20090.046; 131.06\u2009\u00b1\u200919.58 vs 122.07\u2009\u00b1\u200917.72\u2009g\/L, <jats:italic>P<\/jats:italic>\u2009=\u20090.045). The MV duration and ICU hospitalization time were shorter in the early PPF group (13 [9;21] vs 21 [14;30] days, <jats:italic>P<\/jats:italic>\u2009=\u20090.006; 28 [22;36] vs 34 [33;51] days, <jats:italic>P<\/jats:italic>\u2009=\u20090.014). There were no significant differences in the incidence of catheter\u2010related bloodstream infections, 30\u2010day mortality, or nutrition intolerance between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early PPF is an effective and safe enteral nutrition method for patients with LHI receiving TH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.11053","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T09:39:06Z","timestamp":1691055546000},"page":"1409-1415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and safety of early postpyloric feeding during therapeutic hypothermia in patients with large hemispheric infarction: A retrospective cohort study"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-5434","authenticated-orcid":false,"given":"Wenya","family":"Cao","sequence":"first","affiliation":[{"name":"Neurocritical Care Unit, Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Disease Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[{"name":"Neurocritical Care Unit, Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Disease Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Ji","sequence":"additional","affiliation":[{"name":"Neurocritical Care Unit, Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Disease Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiting","family":"Fan","sequence":"additional","affiliation":[{"name":"Neurocritical Care Unit, Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Disease Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Fan","sequence":"additional","affiliation":[{"name":"Neurocritical Care Unit, Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Disease Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Tian","sequence":"additional","affiliation":[{"name":"Neurocritical Care Unit, Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Disease Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurocritical Care Unit, Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Disease Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1093\/ajcn\/47.2.352"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1001\/archneur.1996.00550040037012"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1007\/s12028-017-0469-5"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1097\/CCM.0000000000001525"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"385","article-title":"Chinese consensus for mild hypothermia brain protection","volume":"32","author":"Cerebral Protection In Cardiac Intensive Care Group Neural Regeneration And Repair Committee Chinese Research Hospital Association; 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