{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:31:41Z","timestamp":1789500701962,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies in adults have shown that low baseline muscle mass at intensive care unit (ICU) admission was associated with poor clinical outcomes. However, no information on the relationship between baseline muscle quality or mass and clinical outcomes in critically ill children was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      3775 children were admitted to the pediatric ICU (PICU), 262 were eligible for inclusion. Abdominal computed tomography was performed to assess baseline skeletal muscle mass and quality. Patients were categorized to normal or low group based on the cutoff value for predicting hospital mortality of the skeletal muscle index (SMI; 30.96\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      \/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and skeletal muscle density (SMD; 41.21 Hounsfield units).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Body mass index (BMI) (18.07\u2009\u00b1\u20094.44 vs 15.99\u2009\u00b1\u20094.51) and BMI\u2010for\u2010age\n                      <jats:italic>z<\/jats:italic>\n                      score (0.46 [\u22120.66 to 1.74] vs \u22120.87 [\u22121.69 to 0.05]) were greater in the normal\u2010SMI group, the length of PICU stay was longer in the low\u2010SMI group (16.00 days [8.50\u201332.50] vs 13.00 days [7.50\u201320.00]), and the in\u2010PICU mortality rate in the normal\u2010SMI group (10.00%) was lower than the low\u2010SMI group (22.6%). Children with low SMD had a higher in\u2010PICU mortality rate (25.6% vs 7.7%), were younger (36.00 months [12.00\u2013120.00] vs 84.00 months [47.50\u2013147.50]) and weighed less (16.40 kg [10.93\u201337.25] vs 23.00 kg [16.00\u201345.00]). Mortality was greater in patients with lower SMD and prolonged hospital stay (log\u2010rank,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007). SMD was an independent predictor for length of PICU stay and in\u2010PICU mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low baseline skeletal muscle quality in critically ill children is closely tied with a higher in\u2010PICU mortality and longer PICU stay and is an independent risk factor for unfavorable clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.11084","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T04:11:44Z","timestamp":1698120704000},"page":"589-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship among low baseline muscle mass, skeletal muscle quality, and mortality in critically ill children"],"prefix":"10.1002","volume":"39","author":[{"given":"Yang","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Hospital of Jilin University Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Hospital of Jilin University Jilin University Changchun 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