{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:32:40Z","timestamp":1768084360758,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D deficiency is present in 40%\u201370% of children with intestinal failure (IF), yet there are no published guidelines for repleting and maintaining vitamin D levels in this population. The purpose of this study is to evaluate the efficacy of a standardized vitamin D algorithm in reducing the incidence of deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was performed in children with IF who had at least one serum vitamin D (25\u2010hydroxyvitamin D<jats:sub>3<\/jats:sub>) measurement. Vitamin D levels were compared prealgorithm (2014\u20132016) and during active\u2010algorithm use (2018\u20132020). Vitamin D levels were classified as severe deficiency (&lt;12.5 nmol per L), mild deficiency (12.5\u201339 nmol\/L), insufficiency (40\u201374 nmol\/L), optimal (75\u2013224 nmol\/L), or toxicity (&gt;225 nmol\/L). Descriptive and comparative statistics were calculated using a linear mixed\u2010effects model, with <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight children with IF were enrolled, which included 157 vitamin D measurements (58 in the prealgorithm group and 98 in the active\u2010algorithm group). Algorithm compliance was 4% in the prealgorithm group and 61% in the active\u2010algorithm group. Active\u2010algorithm patients had improved vitamin D levels in all categories compared with those of prealgorithm patients (mild deficiency: 8% vs 9%; insufficiency: 41% vs 72%; optimal: 50% vs 19%). Algorithm use was found to have a statistically significant effect on serum vitamin D levels (<jats:italic>\u03b2<\/jats:italic>\u2009=\u200921.58; 95% confidence interval, 14.11\u201329.05; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children with IF are at high risk for vitamin D deficiency. Use of a standardized vitamin D supplementation algorithm was associated with increased serum vitamin D levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.11094","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T22:44:14Z","timestamp":1701297854000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Standardizing vitamin D supplementation to minimize deficiency in children with intestinal failure"],"prefix":"10.1002","volume":"39","author":[{"given":"Jade","family":"Zhong","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of British Columbia Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debby S.","family":"Martins","sequence":"additional","affiliation":[{"name":"Complex Feeding and Nutrition Service, British Columbia Children's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-2271","authenticated-orcid":false,"given":"Hannah G.","family":"Piper","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery University of British Columbia, British Columbia Children's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602650"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2019.08.003"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"462","article-title":"Nutrition and growth in children","volume":"72","author":"Matonti L","year":"2020","journal-title":"Minerva Pediatr"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10274"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117690528"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.10.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.12.049"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31829c10eb"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350616"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000508"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10685"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1894"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2017-0391"},{"issue":"1","key":"e_1_2_8_16_1","article-title":"Vitamin D deficiency in pediatric clinical practice","volume":"116","author":"Cediel G","year":"2018","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0697-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516003470"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-015-0105-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2175"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115625220"},{"key":"e_1_2_8_22_1","unstructured":"HealthLinkBC. 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