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It occurs in patients with insufficient intestinal surface area and\/or function to maintain metabolic and growth demands. Rapid intestinal transit and impaired bile acid recycling further contribute to fat malabsorption. A significant portion of patients require parenteral nutrition (PN) for their survival but may develop sepsis and liver dysfunction as a result. Despite advancements in the treatment of SBS, fat malabsorption remains a chronic issue for this vulnerable patient population. Peer\u2010reviewed literature was assessed on the topic of fat malabsorption in SBS. Current management of patients with SBS involves dietary considerations, PN management, antidiarrheals, glucagon\u2010like peptide 2 agonists, and multidisciplinary teams. Clinical trials have focused on improving intestinal fat absorption by facilitating fat digestion with pancreatic enzymes. Targeting fat malabsorption in SBS is a potential pathway to improving lifestyle and reducing morbidity and mortality in this rare disease.<\/jats:p>","DOI":"10.1002\/ncp.11119","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T02:35:24Z","timestamp":1709346924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fat malabsorption in short bowel syndrome: A review of pathophysiology and management"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-2388","authenticated-orcid":false,"given":"Thomas I.","family":"Hirsch","sequence":"first","affiliation":[{"name":"Vascular Biology Program, Department of Surgery, Boston Children's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-6665","authenticated-orcid":false,"given":"Sarah 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