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In the setting of cancer cachexia and gastrointestinal toxicities of cancer treatments, untreated (or undertreated) EPI exacerbates weight loss, sarcopenia, micronutrient deficiencies, and malnutrition. Together, these complications contribute to poor tolerance of oncologic therapies and negatively impact survival. Treatment of EPI in PDAC involves the addition of pancreatic enzyme replacement therapy, with titration to improve gastrointestinal symptoms. Medical nutrition therapies may also be applicable and may include fat\u2010soluble vitamin replacement, medium\u2010chain triglycerides, and, in some cases, enteral nutrition. Optimizing nutrition status is an important adjunct treatment approach to improve quality of life and may also improve overall survival.<\/jats:p>","DOI":"10.1002\/ncp.11129","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T02:35:24Z","timestamp":1709346924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fat malabsorption in pancreatic cancer: Pathophysiology and management"],"prefix":"10.1002","volume":"39","author":[{"given":"Gretchen","family":"Murray","sequence":"first","affiliation":[{"name":"Health and Rehabilitation Sciences, College of Medicine, The Ohio State University Columbus Ohio USA"},{"name":"Department of Nutrition Services The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell L.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-6196","authenticated-orcid":false,"given":"Phil A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5619-990X","authenticated-orcid":false,"given":"Kristen M.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Health and Rehabilitation Sciences, College of Medicine, The Ohio State University Columbus Ohio USA"},{"name":"Division of Gastroenterology, Hepatology, and Nutrition The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.065946"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2021.11.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304192881603"},{"issue":"12","key":"e_1_2_8_5_1","first-page":"220","article-title":"Options for addressing exocrine pancreatic insufficiency in patients receiving enteral nutrition supplementation","volume":"23","author":"Freedman SD","year":"2017","journal-title":"Am J Manag Care"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.06.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-015-0057-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000457"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000002016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)91632-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-016-0517-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.03.020"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000951"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i42.7258"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2015.07.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103522"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i32.4698"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11061611"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01301-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2021-000643"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061543"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1404198"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"136","article-title":"Digestive toxicity in cancer treatments. 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