{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:06:12Z","timestamp":1775581572289,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Approximately 85% of patients with cystic fibrosis (CF) have exocrine pancreatic insufficiency (EPI) with 10% requiring supplemental nighttime enteral tube feedings. Administration of pancreatic enzyme replacement therapy (PERT) with nighttime feedings is fraught with challenges. RELiZORB (Alcresta Therapeutics, Inc), an in\u2010line lipase cartridge, delivers PERT continuously with enteral feedings. Outcomes related to the use of this in\u2010line lipase cartridge are lesser known. This project evaluated anthropometrics related to in\u2010line lipase cartridge use among pediatric patients with CF already receiving oral PERT therapy prior to nighttime enteral feedings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective chart review was performed on 29 patients with CF and EPI receiving supplemental tube feedings and utilizing in\u2010line lipase cartridge for a continuous 12 month period between 2015 and 2019. Anthropometrics were evaluated 12 months before and after initiation of in\u2010line lipase cartridge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with mean height\n                      <jats:italic>z<\/jats:italic>\n                      score at 6\u2010months pre\u2013in\u2010line lipase cartridge, mean height\n                      <jats:italic>z<\/jats:italic>\n                      score at 6\u2010months post\u2013in\u2010line\u2010lipase cartridge (adjusted mean difference [AMD]\u2009=\u20090.2540; 95% CI\u2009=\u2009[0.0487, 0.4592];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0153) and mean height\n                      <jats:italic>z<\/jats:italic>\n                      score at 12\u2010months post\u2013in\u2010line lipase cartridge (AMD\u2009=\u20090.2684; 95% CI\u2009=\u2009[0.0203, 0.5166];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0340) were significantly higher. Mean weight\n                      <jats:italic>z<\/jats:italic>\n                      score at 12\u2010months post\u2013in\u2010line\u2010lipase\u2010cartridge neared statistical significance compared with 6\u2010months pre\u2013in\u2010line lipase cartridge (AMD\u2009=\u20090.2816; 95% CI\u2009=\u2009[\u22120.0003, 0.5634];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0502) when excluding seven patients with advanced lung disease (forced expiratory volume in the first second of expiration of 40%). Weight\u2010for\u2010length or body mass index did not significantly differ compared with pre\u2013in\u2010line lipase cartridge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Use of in\u2010line lipase cartridge with enteral feeds improved anthropometrics, especially height, in pediatric patients with CF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.11142","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T02:04:27Z","timestamp":1710641067000},"page":"903-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of in\u2010line digestive enzyme cartridge with enteral feeds on improvement in anthropometrics among pediatric patients with cystic fibrosis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-317X","authenticated-orcid":false,"given":"Samarth","family":"Shrivastava","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Combined Internal Medicine and Pediatrics University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karyn","family":"Shaw","sequence":"additional","affiliation":[{"name":"Pediatric Clinical Nutrition Children's Health Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-506X","authenticated-orcid":false,"given":"MinJae","family":"Lee","sequence":"additional","affiliation":[{"name":"Peter O'Donnell Jr. School of Public Health University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Reitich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacie","family":"Hunter","sequence":"additional","affiliation":[{"name":"Pediatric Clinical Nutrition Children's Health Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Klosterman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghana","family":"Sathe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Cystic Fibrosis Foundation.Patient registry annual data report.Cystic Fibrosis Foundation.https:\/\/www.cff.org\/sites\/default\/files\/2021-11\/Patient-Registry-Annual-Data-Report.pdf"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12214"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.06.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.051409"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S168266"},{"key":"e_1_2_8_7_1","unstructured":"RELIiZORB website.Alcresta Therapeutics Inc.www.relizorb.com"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14071341"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10080"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001617"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002110"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002984"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202008-933OC"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.935354"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10831"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.0206"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124414"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614557642"}],"container-title":["Nutrition 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