{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:38Z","timestamp":1761007478945,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although reuse of enteral feeding equipment has been linked to risk of microbial contamination and risk of infection, there is a paucity of research in this area. Per the manufacturer's instructions low\u2010profile gastrostomy feeding extension sets (LPG\u2010FES) may be reusable for the same patient, but there are no recommendations on replacement intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective observational study to analyze and compare the contamination rate of LPG\u2010FES after 15 (T1) and after 30 days (T2) of regular use. We included children 2\u201318 years of age exclusively receiving long\u2010term home enteral nutrition (HEN) via LPG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 17 patients with a median age of 5 years (interquartile range: 3\u20138 years). We did not find statistically significant differences in microbial overgrowth comparing LPG\u2010FES obtained after 15 or 30 days of use, although overgrowth was slightly higher in LPG\u2010FES used for 30 days (64.7% and 70.6% vs 52.9% and 58.8%). Every patient presented at least one positive culture, either in T1 or T2. <jats:italic>Candida parapsilosis<\/jats:italic> was globally the most frequent microbiological finding. We found no relation between duration of HEN and type of feeding and positive culture at T1 and T2. We found no symptoms of local nor systemic infection during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the high rate of microbial overgrowth in the LPG\u2010FES, no patient had clinical symptoms of infection secondary to this finding. Microbiological isolation in FES may represent only a form of contamination without clinical implications, which raises doubts on possible LPG\u2010FES dwell times.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ncp.11252","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T07:38:17Z","timestamp":1732693097000},"page":"450-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective observational study on microbiological isolation in low\u2010profile gastrostomy's feeding extension sets in children on long\u2010term home enteral nutrition"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-6447","authenticated-orcid":false,"given":"Silvia","family":"Rodriguez\u2010Manchon","sequence":"first","affiliation":[{"name":"Hospital Alvarez Buylla Mieres Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Sanchez Fernandez\u2010Bravo","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Adeslas Pontevedra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Hern\u00e1ndez\u2010Mil\u00e1n","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Clinical Analysis Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Ca\u00f1edo\u2010Villarroya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Alonso\u2010Sanz","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Clinical Analysis Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Pedron\u2010Giner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003207"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108330314"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"1","article-title":"Consensus on paediatric enteral nutrition access: a document approved by SENPE\/SEGHNP\/ANECIPN\/SECP","volume":"26","author":"SENPE's Standardization Group","year":"2011","journal-title":"Nutr Hosp"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.10.018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14112180"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000501"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000001332"},{"key":"e_1_2_8_10_1","unstructured":"Avanos*MIC\u2010KEY*.Low\u2010profile gastrostomy feeding tube\u2014en extension sets with ENFit connector instructions of use. Accessed May 6 2024.\u00a0https:\/\/www.avanos.qarad.eifu.online\/AVA\/all?keycode=000646"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10574"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607116673053"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2001.tb07455.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-146"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.33831"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.34467"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.20005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199210000-00005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.775014"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11061365"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.11252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:42:48Z","timestamp":1760967768000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.11252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ncp.11252"],"URL":"https:\/\/doi.org\/10.1002\/ncp.11252","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"type":"print","value":"0884-5336"},{"type":"electronic","value":"1941-2452"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"2024-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}