{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:14:25Z","timestamp":1792512865803,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The neutropenic diet has been a long\u2010standing approach to preventing infection in patients with hematopoietic stem cell transplants (HSCTs), although data on its efficacy are inconclusive and its restrictive nature might contribute to harm by reducing dietary intake in this patient population who typically experiences poor oral intake. The aim was to determine if a liberalized diet (LD), in comparison with a neutropenic hospital diet (ND), would improve energy intake and lessen weight loss during neutropenia in patients with HSCTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A randomized controlled trial was conducted in a single\u2010center HSCT\/hematologic malignancy unit. The diet interventions were initiated when absolute neutrophil counts dropped to &lt;500\u2009cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ; oral dietary intake was assessed during neutropenia until neutrophil recovery, which averaged 9.5 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Meal intake compliance (consuming at least 50% of meals\/day) was not different between groups (LD, 47%; ND, 43%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.66). Of the 191 patients assessed (LD,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200992; ND,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200999), mean (SD) energy, 678 (349) vs 724 (393)\u2009kcal\/d (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.46), and protein, 30.3 (18.5) vs 30.4 (18.1)\u2009g\/day (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.89) did not differ between groups nor did weight change, 0.3 (2.5) vs 1.2 (4.1)\u2009kg (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.22) during neutropenia. None vs higher than or equal to grade 1 mucositis, allogeneic vs autologous stem cell transplantation, and fewer days on intervention favored higher energy and protein intakes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Energy intake during neutropenia did not improve with a LD encouraging fresh fruits and vegetables. Thus, alternative approaches to improving dietary intake, such as energy\u2010dense and nutrient\u2010dense foods with sensory characteristics acceptable to patients experiencing significant mucositis, require exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.11264","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T05:20:51Z","timestamp":1734672051000},"page":"584-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A liberalized diet does not improve caloric intake during neutropenia in patients undergoing hematopoietic stem cell transplants: A prospective randomized controlled trial"],"prefix":"10.1002","volume":"40","author":[{"given":"Jenna N.","family":"Schulz","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition Services University of Florida Health Shands Hospital Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina H.","family":"McGee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Services University of Florida Health Shands Hospital Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Weaver","sequence":"additional","affiliation":[{"name":"College of Nursing University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Wingard","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, College of Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Precious D.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, College of Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Cline","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, College of Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosha","family":"Farhadfar","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, College of Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Lynch\u2010Kelly","sequence":"additional","affiliation":[{"name":"College of Nursing University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeina A.","family":"Al\u2010Mansour","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, College of Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-4731","authenticated-orcid":false,"given":"Wendy J.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition University of Florida\/IFAS Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(21)20502-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197011)26:5<1076::AID-CNCR2820260516>3.0.CO;2-D"},{"issue":"3","key":"e_1_2_8_4_1","first-page":"515","article-title":"Dietary restrictions for patients with neutropenia: a survey of institutional practices","volume":"27","author":"Smith LH","year":"2000","journal-title":"Oncol Nurs Forum"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119592"},{"key":"e_1_2_8_6_1","unstructured":"Academy of Nutrition and Dietetics.Nutrition Care Manual (NCM).https:\/\/www.nutritioncaremanual.org\/adult-nutrition-care"},{"key":"e_1_2_8_7_1","volume-title":"USDHHS Food Code","author":"U.S. Department of Health and Human Services","year":"2023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.05.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.2985"},{"issue":"6","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1083-8791(00)70002-4","article-title":"Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients","volume":"6","author":"Centers for Disease Control and Prevention; 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