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There is a scarcity of literature regarding the prevalence of SBS\u2010IF and challenges in estimating prevalence. A targeted literature review was conducted to generate prevalence estimates for SBS\u2010IF, primarily defined by the requirement for home PN (HPN), in adults and children across multiple geographies. Country\u2010specific estimates of HPN prevalence and the proportion of HPN cases associated with SBS were obtained from the literature and used to inform SBS\u2010IF prevalence estimates. Adults were defined as those aged \u226518 years and children as those aged 0\u201317 years, except in Japan, where adults were those aged \u226515 years and children were aged 0\u201314 years. In total, 15 studies were included and were used to estimate and extrapolate prevalence across 61 countries for the years 2020\u20132030. The estimated prevalences of diagnosed SBS\u2010IF in the general population in 2024 ranged from 0.12 to 2.74 per 100,000 in adults and 0.09 to 1.67 per 100,000 in children. Prevalence estimates were generally lower in countries with a lower average income. This study provides up\u2010to\u2010date insights into the overall global and country\u2010by\u2010country prevalence of SBS\u2010IF and in defined cohorts of adults and children, addressing important gaps in the current literature.<\/jats:p>","DOI":"10.1002\/ncp.11314","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:09:45Z","timestamp":1747991385000},"page":"1093-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Global prevalence of short bowel syndrome\u2013associated intestinal failure in adults and children: A targeted literature review and analysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0143-1390","authenticated-orcid":false,"given":"Bilal","family":"Khokhar","sequence":"first","affiliation":[{"name":"Takeda Development Center Americas, Inc. 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