{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:51:08Z","timestamp":1791942668763,"version":"4.3.4"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic value of nutrition status assessed by the Patient\u2010Generated Subjective Global Assessment (PG\u2010SGA) in postoperative patients with recurrent or metastatic (R\/M) cancer remains unclear. This study assessed\u00a0whether combining PG\u2010SGA\u2013defined malnutrition with systemic inflammation indices improves mortality prediction accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nutrition status was evaluated via PG\u2010SGA, with systemic inflammation assessed by systemic immune\u2010related inflammation index (SII), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR). Kaplan\u2010Meier and Cox regression analyses examined associations \uff08individual\/combined)\u00a0of PG\u2010SGA\u2013defined malnutrition and systemic inflammation with all\u2010cause mortality. Receiver operating characteristic curves and concordance index (C index) evaluated accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among\u00a0537 postoperative patients with R\/M cancer, multivariable Cox regression analysis showed\u00a0malnutrition significantly increased mortality risk (malnourished: hazard ratio [HR]\u2009=\u20091.82 [95% CI, 1.23\u20132.72;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001]; severely malnourished: HR\u2009=\u20092.46 [95% CI, 1.67\u20133.62;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001]). In joint analysis, severely malnourished patients with high systemic inflammation burden had the highest overall mortality risks. The C index was 0.626 for PG\u2010SGA\u2013SII, 0.630 for PG\u2010SGA\u2013NLR, 0.618 for PG\u2010SGA\u2013PLR, and 0.630 for PG\u2010SGA\u2013MLR. Subgroup analyses revealed amplified composite risks in women, older adults, and those with chemotherapy history.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the synergistic prognostic impact of PG\u2010SGA\u2013assessed malnutrition and systemic inflammation in postoperative R\/M cancer, identifying a high\u2010risk subgroup requiring prioritized nutrition and immunomodulatory interventions. Prospective multi\u2010center validition\u00a0is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.11336","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T02:14:23Z","timestamp":1750126463000},"page":"219-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Systematic inflammation burdens improve the survival prediction value of nutrition assessment in postoperative patients with recurrent or metastatic cancer: A retrospective observational study"],"prefix":"10.1002","volume":"41","author":[{"given":"Ge","family":"Song","sequence":"first","affiliation":[{"name":"Department of Biotherapy and National Clinical Research Center for Geriatrics, Cancer Center, West China Hospital Sichuan University Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Dai","sequence":"additional","affiliation":[{"name":"Department 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