{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:45:21Z","timestamp":1783359921297,"version":"3.54.6"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Lack of central venous line (CVL) sites is a common indication for intestinal transplantation in intestinal failure (IF) patients. For treatment of central line\u2010associated bloodstream infections (CLABSIs), many pediatric gastroenterologists preserve CVL access, but line removal is typically recommended for\n                      <jats:italic>Candida<\/jats:italic>\n                      sp CLABSI due to high risk of systemic complications. However, no data exist on outcomes for IF patients treated for\n                      <jats:italic>Candida<\/jats:italic>\n                      sp CLABSI. This study aims to assess if CVL preservation increases the risk of complications or recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective chart review was conducted for children &lt;18 years of age with IF and\n                      <jats:italic>Candida<\/jats:italic>\n                      sp CLABSI between 2012 and 2023. Patients with blood cultures positive for\n                      <jats:italic>Candida<\/jats:italic>\n                      sp from the CVL were included. Each CLABSI event was analyzed for key variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve patients were included, with 18 events (median age 6.4 years).\n                      <jats:italic>Candida<\/jats:italic>\n                      species identified included\n                      <jats:italic>C albicans<\/jats:italic>\n                      (33.3%) and\n                      <jats:italic>C parapsilosis<\/jats:italic>\n                      (38.9%). Antifungal therapy exceeded 14 days in all events, and ethanol lock therapy (70% concentration) was used in 72%. CVL was removed in 44.4% of events. Five patients had multiple events, with\n                      <jats:italic>Candida<\/jats:italic>\n                      species identified in subsequent infections. No secondary site seeding or long\u2010term sequelae occurred, and no patients died.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our data suggest that CVL preservation in pediatric IF patients with\n                      <jats:italic>Candida<\/jats:italic>\n                      sp CLABSI is feasible without increased complications or mortality. Limitations include small sample size and retrospective design.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.70000","type":"journal-article","created":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T09:20:55Z","timestamp":1753608055000},"page":"1139-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment outcomes in pediatric intestinal failure patients with ambulatory\n                    <i>Candida<\/i>\n                    central line\u2010associated bloodstream infections with and without central venous line removal: A retrospective case series"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-974X","authenticated-orcid":false,"given":"Hamza Hassan","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology Medical University of South Carolina Charleston South Carolina USA"},{"name":"Department of Pediatrics, Division of Gastroenterology University of Arkansas for Medical Sciences Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candi S.","family":"Jump","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology Medical University of South Carolina Charleston South Carolina USA"},{"name":"Department of Pediatrics Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-4524","authenticated-orcid":false,"given":"Stephen","family":"Thacker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3069-7721","authenticated-orcid":false,"given":"Allison Ross","family":"Eckard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases Medical University of South Carolina Charleston South Carolina USA"},{"name":"Department of Medicine, Division of Infectious Diseases Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003065"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003036"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2232"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1667"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114567897"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113517716"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2022.e01559"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.01.035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piv048"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2630"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12175"}],"container-title":["Nutrition 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Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.70000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ncp.70000","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.70000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:26:14Z","timestamp":1772990774000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.70000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,27]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ncp.70000"],"URL":"https:\/\/doi.org\/10.1002\/ncp.70000","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,27]]},"assertion":[{"value":"2025-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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