{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:58:54Z","timestamp":1792522734444,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This meta\u2010analysis aimed to evaluate the effectiveness and reliability of probiotic interventions in managing chemotherapy\u2010induced complications among patients with leukemia, providing evidence\u2010based insights for clinical decision\u2010making. Studies in PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Data were comprehensively searched up to March 5, 2024. Randomized controlled trials (RCTs) comparing probiotic use with conventional care in leukemia patients undergoing chemotherapy were included. The included studies examined all possible chemotherapy\u2010related adverse effects without selective outcome reporting. Data synthesis was conducted using RevMan 5.4 and STATA 15.0. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was used to evaluate the quality of evidence for each outcome. Eight RCTs encompassing 753 participants were analyzed. Compared with conventional care, probiotics significantly reduced constipation (odds ratio [OR]\u2009=\u20090.61, 95% CI\u2009=\u20090.30\u20131.24,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), nausea (OR\u2009=\u20090.51, 95% CI\u2009=\u20090.41\u20130.63],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.00001), chemotherapy\u2010induced diarrhea (OR\u2009=\u20090.39, 95% CI\u2009=\u20090.26\u20130.57],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.00001), bloating (OR\u2009=\u20090.38, 95% CI\u2009=\u20090.20\u20130.76,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006), vomiting (OR\u2009=\u20090.62, 95% CI\u2009=\u20090.39\u20130.98,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04), and indigestion (OR\u2009=\u20090.55, 95% CI\u2009=\u20090.31\u20130.95,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). Notable improvements were observed in procalcitonin and tumor necrosis factor\u2013alpha levels. Evidence quality was high for most outcomes, with moderate ratings for dyspepsia, constipation, and vomiting. In conclusion, probiotic supplementation appears to moderately alleviate chemotherapy\u2010induced complications in patients with leukemia. Nevertheless, because of limitations such as small sample sizes and potential data variability, further validation through large\u2010scale RCTs is necessary.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.70018","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T05:11:00Z","timestamp":1755753060000},"page":"62-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Can probiotics reduce chemotherapy\u2010induced complications in leukemia patients? A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1406-0892","authenticated-orcid":false,"given":"Miaomiao","family":"Chen","sequence":"first","affiliation":[{"name":"Nuclear Radiation Injury Protection and Treatment Department Navy Medical Center of PLA Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Lan","sequence":"additional","affiliation":[{"name":"Nuclear Radiation Injury Protection and Treatment Department Navy Medical Center of PLA Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Huang","sequence":"additional","affiliation":[{"name":"Nuclear Radiation Injury Protection and Treatment Department Navy Medical Center of PLA Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Nuclear Radiation Injury Protection and Treatment Department Navy Medical Center of PLA Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Nuclear Radiation Injury Protection and Treatment Department Navy Medical Center of PLA Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiading Branch of Shanghai General Hospital, School of Medicine Shanghai JiaoTong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"issue":"10","key":"e_1_2_8_2_1","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for 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