{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:59:29Z","timestamp":1787237969420,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Central line\u2010associated bloodstream infections (CLABSI) are a significant cause of morbidity in children with intestinal failure (IF). Probiotic therapy is discouraged in patients with IF because of the increased risk of bacteremia with the probiotic organism. We report an unusual, previously undescribed, clinical presentation of a\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    \u2010species CLABSI linked to yogurt consumption in a toddler with IF secondary to Megacystis\u2013microcolon\u2013intestinal hypoperistalsis syndrome.\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    is abundant in fermented foods like yogurt and among the commensal constituents of the oral cavity microbiome and mucosal surfaces in the gastrointestinal tract. It is rarely implicated as the causative organism in CLABSI. At the time of presentation with fever, blood cultures were collected from the patient's central venous catheter (CVC), and peripherally. Both grew\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    species. Comparative genetic analysis predicted ~99% similarity between the CLABSI isolate and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    isolates from the Greek yogurt the patient regularly consumed. Our patient's\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    CLABSI was linked to the consumption of Greek yogurt. We speculate that daily consumption of yogurt with live cultures posed a high cumulative exposure to\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    species either through external contamination of our patient's CVC or translocation of the ingested organisms from his gastrointestinal tract into the bloodstream. This is the first case report that links CLABSI in children with IF to yogurt consumption.\n                  <\/jats:p>","DOI":"10.1002\/ncp.70025","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T06:20:01Z","timestamp":1756621201000},"page":"968-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of yogurt central line\u2010associated bloodstream infection in a child with intestinal failure"],"prefix":"10.1002","volume":"41","author":[{"given":"Nasiha","family":"Rahim","sequence":"first","affiliation":[{"name":"Section of Gastroenterology, Hepatology &amp; Nutrition, Comer Children's Hospital University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Keller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Advocate Children's Hospital, Advocate Health Care Oaklawn Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition, Lurie Children's Hospital Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8489-7285","authenticated-orcid":false,"given":"Andrea","family":"Berkemeyer","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology &amp; Nutrition, Comer Children's Hospital University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Johnson","sequence":"additional","affiliation":[{"name":"Dept of Veterinary and Biomedical Sciences University of Minnesota St Paul Minneapolis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Johnson","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Comer Children's Hospital University of Chicago Chicago IIllinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-5142","authenticated-orcid":false,"given":"Timothy","family":"Sentongo","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology &amp; Nutrition, Comer Children's Hospital University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2017-12981"},{"issue":"11","key":"e_1_2_8_3_1","article-title":"Alarming antibiotic resistance of Lactobacilli isolated from probiotic preparations and dietary supplements","volume":"11","author":"Anisimova E","year":"2022","journal-title":"Antibiotics (Basel, Switzerland)"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00080-13"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1226"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2289704"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb12198.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000154588.79356.e6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005953"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002655"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1599-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1605(93)90043-G"},{"key":"e_1_2_8_13_1","unstructured":"National Institutes of Health Office of Dietary Supplements.Probiotic Fact Sheet for Health Professionals. Accessed October 27 2024.https:\/\/ods.od.nih.gov\/factsheets\/Probiotics-HealthProfessional\/"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"98","article-title":"Poor outcome of rare Lactobacillus bacteremia and endocarditis in a patient with frequent consumption of live culture yogurts","volume":"15","author":"Wasuwanich P","year":"2025","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.5.958"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000308715"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-016-9209-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540110026953"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/425741"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003036"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131919"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.70025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ncp.70025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.70025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:39:47Z","timestamp":1779370787000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.70025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ncp.70025"],"URL":"https:\/\/doi.org\/10.1002\/ncp.70025","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]},"assertion":[{"value":"2025-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}