{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:11:28Z","timestamp":1791659488078,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The cachexia index (CXI) demonstrates potential as both a diagnostic tool for cachexia and a prognostic tool for survival in cancer. However, CXI's predictive value has not been verified in cervical cancer. The purpose of this study is to investigate the prognostic value of the CXI in patients with cervical cancer treated with radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively screened patients diagnosed with cervical cancer who underwent radiotherapy in a single institution between September 2013 to September 2015. The CXI was calculated as the skeletal mass index (SMI) \u00d7 albumin\/neutrophil\u2010to\u2010lymphocyte ratio. SMI was measured by computed tomography using the muscles of the third lumbar vertebra. Survival times were evaluated using the Kaplan\u2010Meier method and Cox proportional hazards regression. A nomogram for predicting survival was developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 81 patients with cervical cancer were included. The cutoff value of the CXI was set at 59.7 using receiver operating characteristic (ROC) analyses. According to this cutoff value, 47 patients were assigned to the high\u2010CXI group, and 34 were assigned to the low\u2010CXI group. The Cox regression analysis showed that a low CXI was associated with decreased overall survival (hazard ratio [HR]: 3.15; 95% confidence interval [CI]: 1.24\u20138.00;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.016). Patients in the low\u2010CXI group also had shorter progression\u2010free survival than those in the high\u2010CXI group, but the difference was of borderline significance (HR: 2.26; 95% CI: 1.00\u20135.11;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The pretreatment CXI is an independent prognostic factor in patients with FIGO II\u2013III cervical cancer treated with radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.70032","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T03:34:22Z","timestamp":1757561662000},"page":"562-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The cachexia index as a prognostic indicator in patients with cervical cancer treated with radiotherapy: A retrospective study"],"prefix":"10.1002","volume":"41","author":[{"given":"Mengxing","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Oncology, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 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