{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:01Z","timestamp":1785445261373,"version":"3.56.0"},"reference-count":112,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic intestinal pseudo\u2010obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction. Pediatric\u2010onset CIPO has higher morbidity and mortality and is termed pediatric intestinal pseudo\u2010obstruction (PIPO) to differentiate it from adult\u2010onset CIPO. PIPO often presents with vague abdominal symptoms such as abdominal pain, distension, bloating, constipation, and diarrhea. Nutrition therapy is the mainstay of the management of PIPO. The main management goals include maintaining an adequate caloric intake, avoiding fluid and electrolyte imbalance, minimizing\/managing malnutrition, treating gastrointestinal symptoms, enhancing intestinal motility using pharmacological interventions, and managing complications such as small intestinal bacterial overgrowth. Surgical interventions are reserved for severe cases. Various modalities of nutrition intervention include modification of oral diet, enteral feeding, and parenteral nutrition. Most children with PIPO have a poor quality of life, and the prognosis is variable based on the underlying condition. Prognosis is better in an interdisciplinary team setting in specialized centers of excellence.<\/jats:p>","DOI":"10.1002\/ncp.70115","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:56:22Z","timestamp":1773111382000},"page":"1048-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Review of nutrition management of pediatric intestinal pseudo\u2010obstruction"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-9703","authenticated-orcid":false,"given":"Senthilkumar","family":"Sankararaman","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Cleveland Clinic Children's Hospital Cleveland Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa Rani","family":"James","sequence":"additional","affiliation":[{"name":"Government Medical College Kozhikode India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"El\u2010Amaireh","sequence":"additional","affiliation":[{"name":"Jordon University of Science and Technology Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-9890","authenticated-orcid":false,"given":"Andrea","family":"Adler","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Cleveland Clinic Children's Hospital Cleveland Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadakkal","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Cleveland Clinic Children's Hospital Cleveland Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujithra","family":"Velayuthan","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Cleveland Clinic Children's Hospital Cleveland Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001047"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2011.09.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2953"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001982"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12945"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb08130.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.04.013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533613485904"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026656513463"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2009.11.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181a15bfe"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10929"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30078-9"},{"issue":"4","key":"e_1_2_6_15_1","first-page":"26","article-title":"Gastroparesis and nutrition: the art","volume":"99","author":"Parrish CR","year":"2011","journal-title":"Pract Gastroenterol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14562"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113479972"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16172955"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2024-006523"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2017.09.005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2011.09.005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2019.18287"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13780"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512003145"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2023.2193887"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719501900105"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90685-1"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.11.010"},{"issue":"5","key":"e_1_2_6_29_1","first-page":"437","article-title":"Lack of lactobezoars in infants given predominantly whey protein formulas","volume":"136","author":"Schreiner RL","year":"1982","journal-title":"Am J Dis Child"},{"issue":"1","key":"e_1_2_6_30_1","first-page":"16","article-title":"Gastrointestinal motility disorders in children","volume":"10","author":"Ambartsumyan L","year":"2014","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12400"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.70161"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(03)00028-1"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.05.004"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH15083"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-004-0025-2"},{"issue":"2","key":"e_1_2_6_37_1","first-page":"140","article-title":"Pediatric gastrointestinal motility disorders: challenges and a clinical update","volume":"4","author":"Chumpitazi B","year":"2008","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90650-X"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000001139"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-007-0033-0"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616662995"},{"key":"e_1_2_6_42_1","unstructured":"Children's Hospital Colorado. Feeding and Swallowing Disorders program: food textures. Revised December 2017. Global Down Syndrome Foundation. Accessed November 1 2025.https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2018\/06\/Food-Textures-Handout-6-2018.pdf"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90262-6"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1980.239.2.G71"},{"key":"e_1_2_6_45_1","unstructured":"The International Dysphagia Diet Standardisation Initiative. Patient handouts. Accessed November 1 2025.https:\/\/www.iddsi.org\/resources\/patient-handouts"},{"key":"e_1_2_6_46_1","unstructured":"GI Nutrition Support Team. Patient education. University of Virginia School of Medicine. Accessed November 1 2025.https:\/\/med.virginia.edu\/ginutrition\/patient-education"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmac037"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.12.006"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90573-6"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2020.19233"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321631"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2019-101181"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17587"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.11216"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17163"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S506561"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES-20-00377"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-015-0034-z"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003850"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2023-006195"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12043"},{"key":"e_1_2_6_62_1","unstructured":"Short Bowel Syndrome. Accessed November 1 2025.https:\/\/www.shortbowelsyndrome.com"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.58427\/apghn.4.4.2025.208-218"},{"key":"e_1_2_6_64_1","unstructured":"United Ostomy Associations of America Inc. Accessed November 1 2025.https:\/\/www.ostomy.org"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020199614102"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112376"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003788"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533610368701"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533611405797"},{"key":"e_1_2_6_70_1","first-page":"1993","volume-title":"GeneReviews","author":"Ambartsumyan L"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003008"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16172966"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2212-6874"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.02.070"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.03.007"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000586"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.06.953"},{"key":"e_1_2_6_78_1","unstructured":"American Society for Parenteral and Enteral Nutrition. Guidelines & standards. Accessed November 1 2025.https:\/\/nutritioncare.org\/clinical-resources\/guidelines-standards"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-08066-1"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.3.395"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040582"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-016-3971-5"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.6.1085"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31824204e4"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2020.23.6.521"},{"issue":"2","key":"e_1_2_6_86_1","first-page":"93","article-title":"Chronic intestinal pseudoobstruction: report of four pediatric patients","volume":"16","author":"Dalgi\u00e7 B","year":"2005","journal-title":"Turk J Gastroenterol"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1545::AID-ANR30>3.0.CO;2-T"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-016-0418-9"},{"issue":"1","key":"e_1_2_6_89_1","first-page":"1","article-title":"Risk of adverse events associated with domperidone and metoclopramide in gastroparesis: systematic review and meta\u2010analysis","volume":"23","author":"Junqueira DR","year":"2023","journal-title":"Drugs R D"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18478"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318167b89d"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.041"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.682"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04907.x"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04456.x"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312229"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225542.03880.68"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80839-0"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(77)90596-6"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.70171"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.51821\/84.3.002"},{"key":"e_1_2_6_102_1","first-page":"2147","volume-title":"Am J Gastroenterol","author":"Murr MM","year":"1995"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-025-06010-0"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.01.084"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.06.002"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950300011"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.20046"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.06.022"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019644022606"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(03)00046-6"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091889"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.08.002"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.837462"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.70115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ncp.70115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ncp.70115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:36:06Z","timestamp":1785443766000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ncp.70115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":112,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ncp.70115"],"URL":"https:\/\/doi.org\/10.1002\/ncp.70115","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"2025-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}