{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:49:08Z","timestamp":1791906548433,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004702","name":"Baxter International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Preoperative parenteral nutrition (PN) improves outcomes in malnourished surgical patients. Traditionally, this requires hospital admission, increasing length of stay and costs\u2014challenges worsened by limited hospital bed availability. Outpatient PN may offer a feasible alternative. This study evaluates the feasibility of administering preoperative PN in an outpatient setting. Malnourished patients scheduled for major surgery, identified using subjective global assessment, received outpatient PN for a median of 5 days (range: 5\u20138) at an infusion clinic. A multichamber, ready\u2010to\u2010use PN solution was infused via a peripherally inserted central catheter (PICC) over 4\u20136\u2009h, delivering 1\u2009L volume, 75.9\u2009g protein, and 950\u2009kcal daily. Feasibility and nutrition outcomes were assessed, along with safety metrics including refeeding syndrome, hyperglycemia, volume overload, and catheter\u2010related complications. Eight patients (four males, four females) participated, with pancreatic cancer being the most common diagnosis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093). All patients completed 100% of planned PN infusions. Median scores reported by patients and nurses for acceptability, appropriateness, and feasibility were consistently high (patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097): acceptability 4.9\/5, appropriateness 4.6\/5, feasibility 4.9\/5; nurses (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093): acceptability 4.3\/5, appropriateness 5.0\/5, feasibility 4.0\/5). Nutritional intake improved with median energy increased from 18.3 to 36.0\u2009kcal\/kg\/day, and protein from 0.90 to 1.5\u2009g\/kg\/day. No complications were reported. Outpatient preoperative PN using multichamber, ready\u2010to\u2010use PN was feasible. This novel approach has the potential to reduce the need for preoperative hospital admission for PN infusion in malnourished surgical patients. Future studies involving larger populations are needed to evaluate the efficacy of outpatient PN.\n                  <\/jats:p>","DOI":"10.1002\/ncp.70118","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:11:36Z","timestamp":1773810696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outpatient preoperative parenteral nutrition in malnourished surgical patients: A feasibility study (the OPPORTUNITY study)"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3166-0856","authenticated-orcid":false,"given":"Narisorn","family":"Lakananurak","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Clinical Nutrition, Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"Department of Medicine, Division of Clinical Nutrition, Faculty of Medicine, King Chulalongkorn Memorial Hospital The Thai Red Cross Society Bangkok Thailand"},{"name":"Department of Medicine, Division of Gastroenterology, Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-0229","authenticated-orcid":false,"given":"Leah","family":"Gramlich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/0884533609332087","article-title":"Comparison of tools for nutrition assessment and screening for predicting the development of complications in orthopedic surgery","volume":"24","author":"Ozkalkanli MY","year":"2009","journal-title":"Nutr Clin 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