{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:05Z","timestamp":1785445265213,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Crohn's Disease Exclusion Diet (CDED) offers a dietary means of inducing and maintaining remission for patients with Crohn's disease (CD). Descriptions of efficacy have emerged primarily from Israel, Europe, and Canada. Here, we offer real\u2010world experience, from a tertiary care center in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective chart review of patients receiving education on the CDED and those adopting the diet. Demographics, medication exposure, disease\u2010related complications, and reported side effects were collected. Corticosteroid\u2010free clinical remission (SF\u2010CR) was measured at weeks 6, 12, and 24 via the pediatric Crohn's Disease Activity Index (PCDAI). Biomarkers were collected at baseline and while on the diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Only 8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932) of children with CD had met with a dietitian regarding the CDED. Of those, 75% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) adopted the diet. A statistically significant change in PCDAI from baseline to weeks 6, 12, and 24 (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      (3)\u2009=\u20099.61,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) was observed. At 24 weeks, SF\u2010CR was achieved in 9\/11 subjects who remained on the diet, with a significant decrease in fecal calprotectin (Wilcoxon signed\u2010rank test\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01, 95% CI). In seven subjects with pre\/post endoscopic assessment, endoscopic response was demonstrated in 71%. Side effects were mild and included increased abdominal pain, diarrhea, and weight loss (37.5%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single\u2010center experience of children with mild to moderate CD who adopted the CDED, adherence was a challenge. However, for those who were able to sustain the diet, the CDED offered a safe and effective means of clinical remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.70122","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:46:41Z","timestamp":1776239201000},"page":"1132-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010center experience of the Crohn's disease exclusion diet in the United States: A retrospective study"],"prefix":"10.1002","volume":"41","author":[{"given":"Mayah","family":"Greenfield","sequence":"first","affiliation":[{"name":"Robert Louis Katz &amp; Manne Research Institute Summer Scholars Program, Northwestern Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Salozzo","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Chen","sequence":"additional","affiliation":[{"name":"Stanley Manne Children's Research Institute, Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Strople","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition, Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Department of Pediatrics Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition, Ann &amp; Robert H. 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