{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:12:13Z","timestamp":1786374733082,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010721","name":"Ironwood Pharmaceuticals, Incorporated","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Short bowel syndrome is a debilitating condition often requiring long\u2010term parenteral support to maintain hydration, nutrition, and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>As part of the noninterventional, cross\u2010sectional Landmark Survey study, we evaluated burdens associated with short bowel syndrome and parenteral support dependency from patient and caregiver perspectives in the United States and Europe. The survey assessed disease\u2010related comorbidities, symptoms\/complications, healthcare resource utilization, employment impact, and quality of life among patients and quality of life, stress, and employment impact among caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200991) frequently reported comorbidities (e.g., Crohn's disease, 25.3%), disabling symptoms\/complications (e.g., fatigue, 73.6%), emergency department visits (41.8%), and overnight hospitalizations (27.5%). Most patients (63.7%) were dependent on both total parenteral nutrition and intravenous hydration: 43.9% and 35.8% reported daily use of each, respectively. Patients experienced substantial impairments in work\u2010 and activity\u2010related productivity and, relative to populations with Crohn's disease and ulcerative colitis, had worse general health and physical health states. Caregivers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966) also reported considerable burden: over half provided care for \u226525\u2009h\/week. Caregivers reported moderate levels of stress, including financial stress (45.5%), feeling overwhelmed (63.6%), and experiencing impacts to their social lives (65.2%) and daily commitments (51.5%). Employed caregivers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926) experienced caregiver\u2010related work impairment (92.0%) and absenteeism (53.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings from the Landmark Survey underscore the substantial and multidimensional burden of short bowel syndrome for patients and caregivers and highlight a critical unmet need for therapies that reduce complications from parenteral support and improve quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.70162","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:11:51Z","timestamp":1786371111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifaceted burden of short bowel syndrome for patients and caregivers: The landmark survey"],"prefix":"10.1002","author":[{"given":"Jenny E.","family":"Harrison","sequence":"first","affiliation":[{"name":"Girls With Guts Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed\u2010Mohammed","family":"Jafri","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopa","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-3869","authenticated-orcid":false,"given":"Vanessa","family":"Kumpf","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Ironwood Pharmaceuticals, Inc. Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-9271","authenticated-orcid":false,"given":"Mena","family":"Boules","sequence":"additional","affiliation":[{"name":"Ironwood Pharmaceuticals, Inc. Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy M.","family":"Yang","sequence":"additional","affiliation":[{"name":"Ironwood Pharmaceuticals, Inc. 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