{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:03:20Z","timestamp":1790708600060,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenic obesity (SO) is a complex geriatric syndrome characterized by excess adiposity and impaired muscle function, in which chronic low\u2010grade inflammation plays a key role. Serum\u2010based inflammatory indices may provide accessible tools for identifying individuals at risk. This study investigated the association between SO and serum\u2010based inflammatory indices and evaluated their discriminative performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 156 older adults (\u226565 years) with obesity, based on retrospectively collected medical records. SO was defined according to European Society for Clinical Nutrition and Metabolism\/European Association for the Study of Obesity criteria. Body composition was assessed using bioelectrical impedance analysis. Serum\u2010based inflammatory indices, including neutrophil\u2010to\u2010lymphocyte ratio (NLR), systemic immune\u2010inflammation index (SII), pan\u2010immune\u2010inflammation value (PIV), monocyte\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, C\u2010reactive protein\u2010to\u2010albumin ratio, and C\u2010reactive protein\u2013albumin\u2013lymphocyte index, were calculated. Multivariable logistic regression analyses were performed, adjusting for age, sex, marital status, polypharmacy, and Clinical Frailty Scale. Receiver operating characteristic (ROC) analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of SO was 28.8%. NLR, SII, and PIV were significantly higher in the SO group (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). In multivariable analyses, NLR (OR 2.56, 95% CI 1.14\u20135.76,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.023), SII (OR 2.38; 95% CI 1.16\u20134.89,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018), and PIV (OR 1.96; 95% CI 1.10\u20133.48,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.022) remained independently associated with SO. ROC analysis demonstrated modest discriminative ability, with AUC values of 0.643 for NLR, 0.628 for SII, and 0.633 for PIV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NLR, SII, and PIV are independently associated with SO; however, their discriminative performance is limited, suggesting they should be used as supportive rather than diagnostic markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.70166","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:32:41Z","timestamp":1786008761000},"page":"1422-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association and discriminative value of serum inflammatory biomarkers for sarcopenic obesity: A retrospective cross\u2010sectional study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1381-3380","authenticated-orcid":false,"given":"Yasemin Polat","family":"\u00d6zer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-5415","authenticated-orcid":false,"given":"Merve","family":"G\u00fcner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Faculty of Medicine Istinye University \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem","family":"Karaduman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics Adana City Training and Research Hospital Adana T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-2077","authenticated-orcid":false,"given":"Mert","family":"E\u015fme","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-1106","authenticated-orcid":false,"given":"Cafer","family":"Balci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu Balam","family":"Do\u011fu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Cankurtaran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem G\u00fclhan","family":"Halil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Faculty of Medicine Hacettepe University Ankara 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