{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T12:12:04Z","timestamp":1788696724956,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The administration of parenteral nutrition (PN) to neonates presents challenges related to the stability and incompatibility of both 2\u2010in\u20101 and 3\u2010in\u20101 admixtures when co\u2010administered with drugs. Incompatibility data derived from adult patients cannot be applied to neonates because of distinct clinical conditions and differences in components of the admixture (e.g., neonatal amino acid formulation). This review presents an overview of the stability and influencing factors, along with the incompatibility of drug\u2013PN mixtures in neonates within the neonatal intensive care unit setting. Various nutritional components and non\u2010nutritional factors such as oxygen, light, pH, temperature, containers, and drugs affect the stability of PN. Patient conditions and the dosage of PN and drugs influence the stability and incompatibility of drug\u2013PN admixtures, whether 2\u2010in\u20101 or 3\u2010in\u20101. Furthermore, assessing identification methods is crucial to ensure precise data regarding the stability and incompatibility of drug\u2013PN. The standardization of PN formulas is essential for the safe administration of PN in neonates; however, individualized PN formulas offer more advantages in addressing specific nutritional requirements. Collaboration among healthcare professionals, including inter\u2010institutional efforts, is essential to establish a consensus on the safe administration of PN to neonates.<\/jats:p>","DOI":"10.1002\/ncp.70176","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T11:23:46Z","timestamp":1788693826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The stability and incompatibility of parenteral nutrition in the neonatal intensive care unit: A narrative review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-1042","authenticated-orcid":false,"given":"Sunandar","family":"Ihsan","sequence":"first","affiliation":[{"name":"Department of Pharmacology Clinical Pharmacy Faculty of Pharmacy, Universitas Halu Oleo Kendari Indonesia"},{"name":"Doctoral Program in Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6698-5621","authenticated-orcid":false,"given":"Fita","family":"Rahmawati","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Clinical Pharmacy Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Mutiara","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Central General Hospital Dr. Cipto Mangunkusumo Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlyn Dian","family":"Laksitorini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta 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