{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:06:42Z","timestamp":1788919602927,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intestinal failure (IF) is a rare condition in which the intestine cannot maintain adequate nutrient absorption to support maintenance and\/or growth. Data on pediatric home parenteral nutrition (HPN) in Korea are limited. We investigated the clinical characteristics of children with IF receiving HPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A nationwide multicenter retrospective study was conducted across 10 tertiary hospitals in Korea from April 2023 to June 2024. Patients who were receiving HPN and had initiated parenteral nutrition (PN) in a hospital at \u226418 years of age were included. Clinical characteristics, including catheter\u2010related bloodstream infection (CRBSI), intestinal failure\u2010associated liver disease (IFALD), micronutrient status, and anthropometric\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores, were analyzed at enrollment and compared with values at HPN initiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 51 patients (median age: 8.4 years) were enrolled. The most common etiologies were chronic intestinal pseudo\u2010obstruction (CIPO, 51%) and short bowel syndrome (39%). The median ages at initiation of PN and HPN were 0.8 and 2.5 years, respectively, and the median duration of PN at study enrollment was 7.7 years. Vitamin D deficiency was the most frequent micronutrient deficiency. From PN initiation to enrollment, 70.6% experienced at least one CRBSI episode (1.57\/1000 catheter days), 17.6% had catheter thrombosis, and 41.2% had IFALD. Growth outcomes demonstrated persistent growth failure. A PN dependency ratio \u226575% was observed in 52.9% of patients at enrollment, indicating limited enteral autonomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This first nationwide Korean cohort study of pediatric IF reveals CIPO as the leading cause. Despite long\u2010term HPN, patients exhibited high PN dependency and persistent growth failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ncp.70178","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:26:56Z","timestamp":1788917216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intestinal failure in children receiving home parenteral nutrition: A Korean multicenter retrospective study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3112-7528","authenticated-orcid":false,"given":"Sun Woo","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Seoul National University Children's Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3969-384X","authenticated-orcid":false,"given":"Kyung Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Children's Hospital Seoul National University College of Medicine Seoul South Korea"},{"name":"Department of Pediatrics Korea University Guro Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-8242","authenticated-orcid":false,"given":"Lia","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Children's Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9760-297X","authenticated-orcid":false,"given":"Jin Soo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Children's Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6449-7819","authenticated-orcid":false,"given":"Jung Ok","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Children's Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6090-1906","authenticated-orcid":false,"given":"Dayoung","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, Seoul National University Children's Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0106-9969","authenticated-orcid":false,"given":"Hyun\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, Seoul National University Children's Hospital Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-5433","authenticated-orcid":false,"given":"Yeoun Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pusan National University Children's Hospital Pusan National University School of Medicine Yangsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-4684","authenticated-orcid":false,"given":"So\u2010Hyun","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery Inje University Busan Paik Hospital Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-7675","authenticated-orcid":false,"given":"Seo\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chonnam National University Children's Hospital Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6374-8356","authenticated-orcid":false,"given":"Ki Soo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jeju National University Hospital Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-2428","authenticated-orcid":false,"given":"Ju Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Eulji University Hospital Daejeon South 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