{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:51:10Z","timestamp":1791975070793,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Protein\u2010energy malnutrition is a common complication in Crohn's disease (CD). In addition to weight loss, patients may develop significant alterations in body composition, including skeletal muscle depletion, which can negatively affect clinical outcomes and quality of life. Herein, we report on a patient with newly diagnosed CD who presented with severe malnutrition and myopenia, which persisted despite improvements in nutritional intake and body weight. A 27\u2010year\u2010old woman was admitted with abdominal pain, decreased appetite, nausea, vomiting, and progressive weight loss (10\u2009kg, 22% of her usual body weight). Based on clinical presentation, family history, and magnetic resonance enterography findings, stricturing CD was diagnosed. Nutritional assessment revealed severe malnutrition (body weight, 31\u2009kg; body mass index, 12.26\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ; phase angle, 4.4\u00b0, intracellular\u2010to\u2010extracellular mass ratio, 0.75). Computed tomography\u2010based body composition analysis demonstrated marked skeletal muscle depletion (skeletal muscle index, 27.5\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    \/m\n                    <jats:sup>2<\/jats:sup>\n                    ), confirming myopenia. The patient was treated with corticosteroids, infliximab, azathioprine, and multidisciplinary nutritional management. After 12 months of follow\u2010up, she achieved clinical remission and gained approximately 25% of her initial body weight. Despite significant weight recovery and improved dietary intake, computed tomography (CT) revealed low skeletal muscle mass and increased visceral and subcutaneous adipose tissue, indicating persistent myopenia. This case highlights the importance of comprehensive body composition assessments in CD. Clinical remission and weight gain may not accurately reflect recovery of skeletal muscle mass. Early nutritional evaluation and longitudinal body composition monitoring may be helpful\u00a0in the management of patients with CD to identify persistent muscle depletion and optimize long\u2010term outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ncp.70191","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:19:41Z","timestamp":1791973181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe malnutrition and persistent myopenia despite weight recovery in newly diagnosed stricturing Crohn's disease: A case report"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-9126","authenticated-orcid":false,"given":"Beatriz Gabriela da","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Medical School S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-9515","authenticated-orcid":false,"given":"Jeniffer Naomy","family":"Nobre","sequence":"additional","affiliation":[{"name":"Medical School, S\u00e3o Jos\u00e9 do Rio Preto (FAMERP) S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4894-0750","authenticated-orcid":false,"given":"Ryan Nunes Yoshio","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1125-2612","authenticated-orcid":false,"given":"Amanda Lu\u00edsa","family":"Spiller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-7906","authenticated-orcid":false,"given":"Matheus Medeiros","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4458-1716","authenticated-orcid":false,"given":"Natalia Salvador","family":"Castelhano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7719-0189","authenticated-orcid":false,"given":"Enya Julia Zucari","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Institute of Biosciences S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9533-4508","authenticated-orcid":false,"given":"Sophia Vidal","family":"Ro\u00e7afa","sequence":"additional","affiliation":[{"name":"Institute of Biosciences S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-4618","authenticated-orcid":false,"given":"Giedre","family":"Soares Prates Herrerias","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-6254","authenticated-orcid":false,"given":"Dani\u00e9la Oliveira","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medical Sciences University of Campinas (UNICAMP) Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-8906","authenticated-orcid":false,"given":"Ligia Yukie","family":"Sassaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School S\u00e3o Paulo State University (Unesp) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.pop.2023.03.009","article-title":"Inflammatory bowel disease","volume":"50","author":"Bruner LP","year":"2023","journal-title":"Prim Care Clin Off 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