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Given the time window of 10\u201320 years from pathological initiation to clinically detected cognitive impairment, early detection can significantly impact the prevention and control of AD. The invasiveness and high cost of cerebrospinal fluid biomarkers and positron emission tomography\u2010computed tomography imaging limit large\u2010scale disease screening. However, blood\u2010based biomarkers (BBMs) lack these disadvantages, shedding light on their usefulness in the large\u2010scale identification and prevention of AD. Prominent advancement has recently been made regarding BBMs of AD co\u2010pathology (amyloid \u03b2, tau protein, neurofilament light polypeptide, and glial fibrillary acidic protein) to improve their accuracy as clinical diagnostics of AD to a level comparable to that of canonical methods, facilitating the large\u2010scale clinical implementation of diagnostic tests with higher precision. To briefly summarize, the prospects of AD BBMs rely on standardization and comprehensiveness. Calibrating the sample collection procedure and clarifying the boundaries for indices and abnormalities are beneficial for constructing a canonical diagnostic assay. The comprehensive assembly of heterogeneous clinical evidence guarantees the accuracy of diagnosis and improves the workflow for early identification.<\/jats:p>","DOI":"10.1002\/nep3.58","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T06:14:00Z","timestamp":1729491240000},"page":"246-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Blood\u2010based biomarkers of Alzheimer's disease: Standardization and comprehensiveness"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-9109","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Neurology and National Center for Neurological Disorders Huashan Hospital, Shanghai Medical College, Fudan University Shanghai 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