{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:37:09Z","timestamp":1767170229637,"version":"3.48.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuroprotection"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear. Network toxicology and molecular docking strategies identified 38 shared targets between isoflurane (PubChem\/ChEMBL) and POD (GeneCards). Protein\u2010protein interaction networks (STRING\/Cytoscape) screened eight core genes: catechol\u2010O\u2010methyltransferase (\n                    <jats:italic>COMT<\/jats:italic>\n                    ), angiotensin l\u2010converting enzyme (\n                    <jats:italic>ACE<\/jats:italic>\n                    ), solute carrier family 6, member 3 (\n                    <jats:italic>SLC6A3<\/jats:italic>\n                    ), cathepsin B (\n                    <jats:italic>CTSB<\/jats:italic>\n                    ), apoptosis\u2010related cysteine peptidase (\n                    <jats:italic>CASP3<\/jats:italic>\n                    ), B\u2010lymphoblastoma\u20102 gene (\n                    <jats:italic>BCL\u20102<\/jats:italic>\n                    ), coagulation factor VII (\n                    <jats:italic>F7<\/jats:italic>\n                    ), and nuclear receptor subfamily 3 (\n                    <jats:italic>NR3C1<\/jats:italic>\n                    ). Functional enrichment (Gene Ontology [GO]\/Kyoto Encyclopedia of Genes and Genomes [KEGG]) analyzed biological pathways. Key pathways implicated include calcium signaling, dopamine\/catecholamine synaptic uptake, cholinergic synapses, endocrine resistance, and estrogen signaling. Molecular docking confirmed strong binding affinity between isoflurane and core targets (e.g.,\n                    <jats:italic>CASP3<\/jats:italic>\n                    : affinity\u20135.54\u2009kcal\/mol), highlighting dopaminergic disruption and apoptotic activation. This study elucidates isoflurane's multi\u2010target neurotoxicity in POD, providing a mechanistic foundation for mitigating postoperative neurological complications.\n                  <\/jats:p>","DOI":"10.1002\/nep3.70015","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T09:29:46Z","timestamp":1757928586000},"page":"386-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-6234","authenticated-orcid":false,"given":"Zhiming","family":"Dai","sequence":"first","affiliation":[{"name":"Surgical Anesthesia Center The First People's Hospital of Xianyang Xianyang Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Nan","sequence":"additional","affiliation":[{"name":"Surgical Anesthesia Center The First People's Hospital of Xianyang Xianyang Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Xi'an Medical University Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Xi'an Shaanxi 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